摘要
目的:探讨高维持剂量枸橼酸咖啡因治疗早产儿原发性呼吸暂停的临床疗效及安全性。方法:选取2017年6月~2019年6月本院收治的86例原发性呼吸暂停早产儿作为研究对象,按照随机数字表法分为观察组和对照组,各43例。对照组给予低维持剂量枸橼酸咖啡因注射液治疗,观察组给予高维持剂量枸橼酸咖啡因注射液治疗。比较两组呼吸暂停次数、呼吸暂停症状消失时间、临床疗效、不良反应及并发症。结果:观察组呼吸暂停次数少于对照组、呼吸暂停症状消失时间短于对照组(P<0.05);观察组总有效率(90.70%)高于对照组(72.09%,P<0.05);两组不良反应及并发症发生率比较无统计学差异(P>0.05)。结论:高维持剂量枸橼酸咖啡因治疗早产儿原发性呼吸暂停,可有效缓解患儿呼吸暂停症状,临床疗效确切,且安全性较好。
Objective:To investigate the clinical efficacy and safety of high maintenance dose of caffeine citrate in the treatment of primary apnea in premature infants.Methods:A total of 86 premature infants with primary apnea treated in our hospital from June 2017 to June 2019 were selected as research subjects,and they were divided into observation group and control group according to the random number table method,43 cases in each group.The control group was treated with low maintenance dose of citrate caffeine injection and the observation group was treated with high maintenance dose of citrate caffeine injection.The apnea times,disappearance time of apnea symptoms,clinical efficacy,adverse reactions and complications were compared between the two groups.Results:The apnea times in the observation group was less than that in the control group,and the disappearance time of apnea symptoms was shorter than that in the control group(P<0.05).The total effective rate of observation group(90.70%)was higher than that of control group(72.09%,P<0.05).There was no significant difference in the incidence of adverse reactions and complications between the two groups(P>0.05).Conclusion:High maintenance dose of caffeine citrate in the treatment of primary apnea in preterm infants can effectively relieve the symptoms of apnea in preterm infants.It has definite clinical efficacy and good safety.
作者
黄玉焕
HUANG Yu-huan(Department of Neonatology,Nanyang First People's Hospital,Nanyang 473002,China)
出处
《中国合理用药探索》
2021年第9期54-57,共4页
Chinese Journal of Rational Drug Use
