摘要
缺血性中风(ischemic stroke,IS)因其高发病率、高死亡率、高致残率和高复发率的特点成为目前导致长期、严重残疾的主要原因之一。目前临床上对于IS的治疗仅有唯一被批准使用的重组组织型纤维蛋白酶原激活剂,但因其时间窗较窄并有许多相对禁忌症包括使临床用药受到很大的限制。所以,开发新型高效的IS神经保护类药物具有重要的临床意义。近年来多肽类药物由于其低毒性、高靶向性和特异性的特点受到广泛关注,外源性应用多肽类药物对IS的防治作用也被报道。本文通过综述多种类型的多肽类药物对IS的防治作用及机制,为新型高效的IS神经保护类药物的开发提供新的分子与研究思路。
Ischemic stroke(IS)is one of the main causes of long-term and severe disability due to its high incidence rate,mortality rate,disability rate,and recurrence rate.At present,there is only the only approved recombinant tissue-type plasminogen activator for the treatment of is in the clinic.However,due to its narrow time window and many relative contraindications,the clinical medication is greatly limited.Therefore,the development of new and efficient is neuroprotective drugs has important clinical significance.In recent years,peptide molecular have attracted extensive attention due to their low toxicity,high targeting,and specificity.The prevention and treatment effect of exogenous peptide molecular on IS has also been reported.In this paper,we reviewed the preventive and therapeutic effects and mechanisms of various peptide molecule on IS and provided new molecular biological templates and research ideas for the development of new and efficient neuroprotective drugs for IS.
作者
尹赛格
孙俊
杨新旺
YIN Sai-ge;SUN Jun;YANG Xin-wang(Dept.of Anatomy and Histology&Embryology,Faculty of Basic Medical Science,Kunming Medical University,Kunming Yunnan 650500,China)
出处
《昆明医科大学学报》
CAS
2021年第9期156-161,共6页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81760648)
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-161)]。
