摘要
目的探讨高血压对中国北方青年女性急性冠状动脉综合征(ACS)的患病和冠状动脉病变程度的影响,为临床防治提供参考。方法回顾性分析2007年1月至2016年12月间,因胸痛或胸部不适症状入院做冠状动脉造影检查的青年女性患者840例,年龄<45岁。依据患者是否患有高血压分为高血压组(n=256例)和对照组(n=584)。观察两组患者中ACS的患病危险因素和患病率及冠状动脉植入支架情况。结果高血压组ACS患病率为80.9%,对照组为36.5%,两组比较差异有统计学意义(P<0.05)。高血压组与对照组中的患者合并高脂血症者为37.1%比14.9%,高胆固醇血症为8.6%比3.4%,高尿酸血症为18.4%比7.2%,高同型半胱氨酸血症为10.9%比3.9%(均P<0.05)。高血压组与对照组中的患者合并超重者为63.7%比29.5%(P<0.05),早发冠心病家族史为15.2%比5.5%,吸烟为5.5%比4.3%,绝经者为4.7%比1.7%,2型糖尿病为24.2%比8.9%(均P<0.05)。高血压组与对照组的冠状动脉双支病变为14.1%比5.7%(P<0.05)。高血压组ACS患者植入支架的数量[(1.67±1.05)支]和支架的长度[(24.44±6.97)mm]大于对照组植入支架的数量[(1.41±0.85)支]和长度[(22.85±7.80)mm],组间比较差异有统计学意义(均P<0.05)。结论高血压是中国北方青年女性ACS患病的重要危险因素。女性高血压患者表现更多的危险因素聚集,高血压与ACS患病独立相关。
Objective To investigate the effect of hypertension on the prevalence of acute coronary syndrome(ACS)and the severity of coronary artery disease in young women in northern China,so as to provide reference for clinical prevention and treatment.Methods A retrospective analysis was performed on 840 young female patients(age<45 years old)underwent coronary angiography due to chest pain or chest discomfort between January 2007 and December 2016.The patients were divided into hypertension group(256 cases)and control group(584 cases)according to whether they had hypertension or not.The risk factors of ACS,the prevalence of ACS and coronary stents implantation in the two groups were observed.Results The prevalence of ACS was 80.9%in the hypertension group and 36.5%in the control group.There was significant difference between the two groups(P<0.05).In the hypertension group and the control group,the rate of patients with hyperlipidemia was 37.1%vs 14.9%,with hypercholesterolemia was 8.6%vs 3.4%,with hyperuricemia was 18.4%vs 7.2%,and with hyperhomocysteinemia was 10.9%vs 3.9%,and there were significant differences between the two groups(all P<0.05).In the hypertension group and control group,the rate of overweight was 63.7%vs 29.5%,family history of early coronary heart disease was 15.2%vs 5.5%,smoking was 5.5%vs 4.3%,menopause was 4.7%vs 1.7%,and type 2 diabetes was 24.2%vs 8.9%,and there were statistically significant(all P<0.05).Double branch lesions of coronary artery in hypertension group and control group were 14.1%and 5.7%respectively(P<0.05).The number(1.67±1.05)and the length[(24.44±6.97)mm]of stents implantation in hypertension patients with ACS were both larger than the number(1.41±0.85)and length[(22.85±7.80)mm]of stents implanted in the control group.The difference between the groups was statistically significant(P<0.05).Conclusions Hypertension is the main risk factor of ACS in young women in northern China.Young women with hypertension have more risk factors for atherosclerotic cardiovascular disease,and hypertension is independently associated with ACS.
作者
刘睿方
徐方兴
刘同库
周玉杰
赵迎新
杨士伟
闫振娴
LIU Rui-fang;XU Fang-xing;LIU Tong-ku;ZHOU Yu-jie;ZHAO Ying-xin;YANG Shi-wei;YAN Zhen-xian(Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,100029,China;Heart Center,Affiliated Hospital of Beihua University)
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2021年第9期841-846,共6页
Chinese Journal of Hypertension
基金
中国医师协会阳光心血管研究基金项目资助课题(SCRFCMDA201214)。
关键词
青年女性
高血压
冠心病
急性冠状动脉综合征
young women
hypertension
coronary heart disease
acute coronary syndrome
