摘要
目的探究胆碱酯酶(ChE)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)与老年维持性透析患者感染可能性评分(IPS)分值的关系及联合诊断导管相关感染的价值。方法选取安徽省六安市中医院血液净化中心老年维持性透析患者102例,根据是否发生导管相关感染分为感染组(28例)与未感染组(74例),比较两组临床资料、IPS评分、血清ChE、hs-CRP、PCT水平,分析各血清指标与IPS评分、导管相关感染的关系,评价血清ChE、hs-CRP、PCT诊断价值。结果感染组透析时间≥1年患者比例71.43%(20/28)、贫血患者比例42.86%(12/28)、低蛋白血症患者比例50.00%(14/28)、糖尿病患者比例35.71%(10/28)、IPS分值(14.02±2.79)分均高于未感染组,差异有统计学意义(P<0.05);感染组血清ChE低于未感染组,血清hs-CRP、PCT水平高于未感染组,差异有统计学意义(P<0.05);血清ChE与老年维持性透析患者IPS分值呈负相关,hs-CRP、PCT与IPS分值呈正相关,且均为导管相关感染发生的影响因素(P<0.05);血清ChE、hs-CRP、PCT联合诊断导管相关感染的曲线下面积(AUC)为0.923。结论血清ChE、hs-CRP、PCT与老年维持性透析患者IPS分值密切相关,各指标联合在导管相关感染诊断方面具有较高诊断效能。
Objective To explore the relationship and joint diagnosis of cholinesterase(ChE),high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT) and the infection probability score(IPS)of elderly maintenance dialysis patients and the value of catheter-related infections.Methods A total of 102 elderly maintenance dialysis patients in Blood Purification Center,Lu’an Hospital of Traditional Chinese Medicine were selected and divided into an infected group(28 cases) and an uninfected group(74 cases) according to whether they had catheter-related infections.The clinical data,IPS scores,and serum levels of ChE,hsCRP,and CRP were compared between the two groups.The relationship between the serum indicators and IPS score,catheter-related infection was analyzed,and the diagnostic value of serum ChE,hs CRP and PCT was evaluated.Results In the infection group,the proportion of patients with dialysis time≥1 year was 71.43%(20/28),the proportion of anemia patients was 42.86%(12/28),the proportion of hypoproteinemia patients was 50.00%(14/28),and the proportion of diabetic patients was 35.71%(10/28).The IPS score(14.02±2.79) was higher than that of the uninfected group,and the difference was statistically significant(P<0.05).The serum ChE of the infected group was lower than that of the uninfected group,and the serum hs-CRP and PCT levels were higher than those of the uninfected group.In the infection group,the difference was statistically significant(P<0.05).Serum ChE was negatively correlated with the IPS scores of elderly maintenance dialysis patients,and hs-CRP,PCT and IPS scores were positively correlated,and they were all affected by the occurrence of catheter-related infections factors(P<0.05).The area under the curve(AUC) for the combined diagnosis of serum ChE,hs-CRP,and PCT for catheter-related infections was 0.923.Conclusion Serum ChE,hs-CRP,PCT are closely related to the IPS score of elderly maintenance dialysis patients,and the combination of these indicators has a high diagnostic efficiency in the diagnosis of catheter-related infections.
作者
张世同
束永兵
方美双
宣文
ZHANG Shitong;SHU Yongbing;FANG Meishuang;XUAN Wen(Blood Purification Center,Lu'an Hospital of Traditional Chinese Medicine,Lu'an,Anhui,China,237000)
出处
《分子诊断与治疗杂志》
2021年第9期1398-1401,共4页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金委员会(1508085MH198)。
关键词
维持性透析
导管相关感染
胆碱酯酶
超敏C反应蛋白
降钙素原
感染可能性评分
Maintenance dialysis
Catheter-related infection
Cholinesterase
High-sensitivity C-reactive protein
Procalcitonin
Infection probability score
