摘要
目的观察化瘀通络灸法结合常规针刺治疗脑卒中后轻度认知障碍(mild cognitive impairment,MCI)患者的临床疗效及其对血液相关因子的影响。方法将60例脑卒中后MCI患者随机分为对照组与观察组,每组30例。两组均采用常规治疗,观察组在此基础上加用化瘀通络灸法治疗。治疗2周后,观察两组患者认知功能状态和血清同型半胱氨酸(homocysteine,Hcy)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)和超氧化物歧化酶(superoxide dismutase,SOD)水平的变化。结果观察组临床疗效明显优于对照组(P<0.05)。与治疗前比较,两组治疗后蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易智力状态检查量表(mini-mental state examination,MMSE)评分均明显升高(P<0.05),且观察组治疗后MoCA、MMSE评分升高程度显著大于对照组(P<0.05)。与治疗前比较,两组治疗后血清SOD水平均显著升高(P<0.05),hs-CRP和血浆Hcy水平均明显下降(P<0.05);且治疗后观察组血清SOD升高程度明显大于对照组(P<0.05),血清hs-CRP和血浆Hcy降低程度明显大于对照组(P<0.05)。结论化瘀通络灸结合常规针刺治疗脑卒中后MCI,可降低炎症水平,清除氧自由基,显著改善患者的认知功能。
Objective To investigate the clinical effect of blood stasis-removing and collateral-dredging moxibustion combined with conventional acupuncture in the treatment of patients with mild cognitive impairment(MCI)after stroke and its influence on related blood factors.Methods A total of 60 patients with MCI after stroke were randomly divided into control group and observation group,with 30 patients in each group.The patients in the control group were treated with conventional acupuncture,and those in the observation group were treated with blood stasis-removing and collateral-dredging moxibustion in addition to the treatment in the control group.After 2 weeks of treatment,the two groups were observed in terms of the changes in the status of cognitive function and the levels of homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP),and superoxide dismutase(SOD).Results The observation group had a significantly better clinical outcome than the control group(P<0.05).After treatment,both groups had significant increases in Montreal Cognitive Assessment and Mini-Mental State Examination scores(P<0.05),and the observation group had significantly greater increases than the control group(P<0.05).After treatment,both groups had a significant increase in the serum level of SOD(P<0.05)and significant reductions in the serum level of hs-CRP and the plasma level of Hcy(P<0.05),and compared with the control group,the observation group had a significantly greater increase in the serum level of SOD(P<0.05)and significantly greater reductions in the serum level of hs-CRP and the plasma level of Hcy(P<0.05).Conclusion In the treatment of post-stroke cognitive impairment,blood stasis-removing and collateral-dredging moxibustion combined with conventional acupuncture can reduce the level of inflammation,scavenge oxygen free radicals,and significantly improve cognitive function.
作者
汪林英
肖洪波
张庆萍
杨骏
张金静
乔晓迪
WANG Lin-ying;XIAO Hong-bo;ZHANG Qing-ping;YANG Jun;ZHANG Jin-jing;QIAO Xiao-di(The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Hefei 230031, China;College of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Anhui Hefei 230012, China)
出处
《安徽中医药大学学报》
CAS
2021年第5期40-44,共5页
Journal of Anhui University of Chinese Medicine
基金
国家自然科学基金项目(81373744)
安徽省“十三五”省级中医重点专科建设项目(中医药服务秘〔2017〕567号)
杨骏全国中医药名老中医传承工作室(国中医药人教发〔2016〕42号)。
关键词
脑卒中
轻度认知功能障碍
化瘀通络灸
同型半胱氨酸
超敏C反应蛋白
超氧化物歧化酶
Stroke
Mild cognitive impairment
Blood stasis-removing and collateral-dredging moxibustion
Homocysteine
High-sensitivity C-reactive protein
Superoxide dismutase
