摘要
目的:观察滋肾养心补血汤联合卵泡期长方案对体外受精-胚胎移植(in vitro fertilization-emryo transfer,IVF-ET)中卵巢功能正常患者促排卵效果的影响。方法:200例行IVF-ET的卵巢储备功能正常不孕患者,随机分为对照组(卵泡期长方案)和治疗组(滋肾养心补血汤+卵泡期长方案),每组各100例。比较两组促性腺激素(gonadotropin,Gn)总用量及使用时间、Gn启动日及绒毛膜促性腺激素(human chorionic gonadotropin,HCG)注射日激素水平、子宫内膜厚度、获卵数、双原核数、成熟卵母细胞率、双原核受精率、卵裂率、优质胚胎率、因卵巢过度刺激综合征高危倾向取消移植率、着床率、临床妊娠率、早期流产率及中医证候积分。结果:与对照组比较,治疗组Gn总用量及使用时间均显著减少(P<005);两组患者HCG日内膜厚度比较,差异无统计学意义(P>0.05)。两组患者Gn启动日促卵泡激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇水平比较,差异无统计学意义(P>0.05);两组患者HCG日LH、孕酮水平比较,差异无统计学意义(P>0.05)。两组患者获卵数、双原核数、平均移植胚胎数比较,差异无统计学意义(P>0.05)。两组患者治疗后证候积分比较,差异有统计学意义(P<0.05);治疗组治疗后证候积分低于对照组治疗后,差异有统计学意义(P<0.05)。两组患者成熟卵母细胞率、双原核受精率、卵裂率、优质胚胎率比较,差异均无统计学意义(P>0.05)。两组早期流产率比较,差异有统计学意义(P<0.05);两组因卵巢过度刺激综合征高危倾向取消移植率、临床妊娠率、着床率比较,差异均无统计学意义(P>0.05)。结论:滋肾养心补血汤能改善IVF-ET中患者临床症状,减少Gn用量、用药时间,降低中医证候评分和早期流产率。
Objective:To observe the effect of Zishen Yangxin Buxue Decoction combined with long follicular Phase plan on ovulation induction in patients with normal ovarian function in in vitro fertilization-emryo transfer(IVF-ET).Methods:200 infertile patients with normal ovarian reserve function undergoing IVF-ET were randomly divided into control group(long follicular Phase plan)and treatment group(Zishen Yangxin Buxue Decoction+long follicular Phase plan),with 100 cases in each group.The total dosage and use time of gonadotropin(Gn),the hormone level on the start-up day of Gn and the injection day of human chorionic gonadotropin(HCG),endometrial thickness,number of oocytes retrieved,number of double pronucleus,rate of mature oocytes,rate of double pronucleus fertilization,cleavage rate,rate of high-quality embryos because of the high risk tendency of ovarian hyperstimulation syndrome,the transplantation rate,implantation rate,clinical pregnancy rate,early abortion rate and TCM syndrome score were compared.Results:Compared with the control group,the total dosage and use time of Gn in the treatment group were significantly reduced(P<0.05);there was no significant difference in HCG daily intimal thickness between the two groups(P>0.05).There was no significant difference in the levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)between the two groups on the day ofGn initiation(P>0.05);there was no significant difference between the two groups in the levels of LH and progesterone on HCG day(P>0.05).There was no significant difference in the number of eggs,double pronucleus and average number of transferred embryos between the two groups(P>0.05).There was significant difference in syndrome scores between the two groups after treatment(P<0.05);the syndrome score of the treatment group was lower than that of the control group(P<0.05).There was no significant difference in mature oocyte rate,double pronuclear fertilization rate,cleavage rate and high-quality embryo rate between the two groups(P>0.05).There was significant difference in early abortion rate between the two groups(P<0.05);there was no significant difference in the cancellation rate of transplantation,clinical pregnancy rate and implantation rate between the two groups due to the high-risk tendency of ovarian hyperstimulation syndrome(P>0.05).Conclusion:Zishen Yangxin Buxue Decoction can improve the clinical symptoms of patients in IVF-ET,reduce the dosage and medication time of Gn,and reduce the score of TCM syndrome and the rate of early abortion.
作者
卫爱武
肖惠冬子
宋艳丽
WEI Aiwu;XIAO HUI Dongzi;SONG Yanli(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The First Affliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2021年第11期2465-2469,共5页
Acta Chinese Medicine
基金
国家自然科学基金项目(81673735)
河南省中医药科学研究专项项目(2014ZY02093)。
关键词
滋肾养心补血汤
卵泡期长方案
体外受精-胚胎移植
卵巢功能
Zishen Yangxin Buxue Decoction
long follicular Phase plan
in vitro fertilization-emryo transfer(IVF-ET)
ovarian function
