摘要
目的探讨双相情感障碍(BPD)患者血清尿酸(UA)、转化生长因子-β(TGF-β)、神经生长因子(NGF)水平及其与病情的相关性和表达意义。方法回顾性选取2019年1月至2020年1月河北医科大学第一医院收治的100例BPD患者作为观察组,另选取100例健康体检者作为对照组。对比两组基础资料、血清UA、TGF-β、NGF水平,分析BPD发病影响因素及血清UA、TGF-β、NGF间相关性,并分析血清UA、TGF-β、NGF对BPD及BPD患者抑郁、躁狂混合发作的诊断价值。结果两组空腹血糖、TG、TC、HDL-C、LDL-C、UA、TGF-β、NGF水平相比,差异有统计学意义(P<0.05);经logistic回归分析可知,空腹血糖、TG、TC、HDL-C、LDL-C、UA、TGF-β、NGF水平均为BPD发病影响因素(P<0.05);BPD患者血清UA与TGF-β、NGF呈负相关(r=-0.744,-0.754,P<0.05),TGF-β与NGF呈正相关(r=0.824,P<0.05);血清UA、TGF-β、NGF诊断BPD的AUC值均较高,尤以联合诊断最高,达0.844;混合发作组血清UA水平高于单一发作组,血清TGF-β、NGF水平低于单一发作组,差异有统计学意义(P<0.05);血清UA、TGF-β、NGF水平对BPD患者抑郁、躁狂混合发作均具有较高诊断价值,联合诊断AUC值最高,达0.770。结论BPD患者血清UA、TGF-β、NGF均异常表达,可能是BPD的生物标记物,且各指标间存在一定相关性,联合检查可提高对BPD及BPD患者抑郁、躁狂混合发作的诊断价值,为早期诊治提供依据。
Objective To explore the relationship between uric acid(UA),transforming growth factor-β(TGF-β),nerve growth factor(NGF)and bipolar disorder(BPD)and its clinical significance.Methods From January 2019 to January 2020,100 BPD patients in the First Hospital of Hebei Medical University were selected as the observation group,and 100 healthy subjects were selected as the control group.The general data,serum UA,TGF-β,and NGF levels were compared between the two groups,and the factors affecting the incidence of BPD and the correlation between serum UA,TGF-β,and NGF were analyzed.And the diagnostic value of serum UA,TGF-β,and NGF on BPD and BPD patients with mixed episodes of depression and mania was analyzed.Results There were statistically significant differences in the levels of fasting blood glucose,triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),UA,TGF-βand NGF between the two groups(P<0.05).Logistic regression analysis showed that fasting blood glucose,TG,TC,HDL-C,LDL-C,UA,TGF-β,and NGF levels were all influencing factors of BPD(P<0.05).Serum UA of BPD patients was negatively correlated with TGF-βand NGF(r=-0.744,-0.754,P<0.05),and TGF-βwas positively correlated with NGF(r=0.824,P<0.05).The area under the curve(AUC)values of serum UA,TGF-β,and NGF in the diagnosis of BPD were all high,especially the highest in combined diagnosis,reaching 0.844.The serum UA level of the mixed episode group was higher than that of the single episode group,and the serum TGF-βand NGF levels were lower than that of the single episode group,the difference was statistically significant(P<0.05).Serum UA,TGF-β,and NGF levels had high diagnostic value for depression and manic mixed episodes in BPD patients,and the combined diagnosis had the highest AUC value,reaching 0.770.Conclusions The serum UA,TGF-β,and NGF of BPD patients are all abnormally expressed,which may be biomarkers of BPD,and there is a certain correlation between the indicators.The combined examination can improve the diagnostic value of mixed episodes of depression and mania in BPD and BPD patients,and provide a basis for early diagnosis and treatment.
作者
王金成
殷慧
杨媛
王冉
宋美
Wang Jincheng;Yin Hui;Yang Yuan;Wang Ran;Song Mei(Department of Psychiatry,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China)
出处
《中国医师杂志》
CAS
2021年第9期1352-1356,共5页
Journal of Chinese Physician
基金
2020年度河北省医学科学研究课题计划(20201144)。
关键词
双相情感障碍
尿酸
转化生长因子Β
神经生长因子
Bipolar disorder
Uric acid
Transforming growth factor beta
Nerve growth factor
