摘要
本文系统介绍了微流激光生化传感机理及其研究进展。基于增益介质调节的微流激光生化传感技术,利用光学微腔内增益介质的数量或状态变化影响激光输出特性;基于微腔调节的微流激光生化传感技术,利用光学微腔性质的变化,引起谐振条件变化,进而引起激光模式、波长或输出方向的变化;基于损耗调节的微流激光生化传感技术,主要包括吸收损耗和散射损耗,待测物或其化学产物对激光产生散射或吸收,使激光强度下降,从而实现生化传感。由于微腔的增敏和激光的放大作用,激光输出特性对腔内生化过程的变化十分敏感,因此微流激光可实现高灵敏、高通量的生化传感。
Optofluidic laser has shown great potential in biochemical sensing.Here in this review,we systematically introduced the sensing mechanism and research progress of optofluidic laser based biochemical sensors.The gain medium regulated optofluidic laser sensing mainly depends on the quantity and state of gain molecules.When the biochemi-cal reaction or molecules change the characteristics of microcavity,the resonance condition changes accordingly,and the change can be reflected and read out in the modes,wavelength and emission direction of lasing light.Furthermore,the biochemical molecules can intro-duce absorption loss and scattering loss in the laser cavity,causing measurable deterioration in laser intensity.Thanks to the amplification of lasing process and optical microcavity,and the narrow linewidth of laser,the laser output characteristics are ultrasensitive to the subtle changes of biochemical process to achieve high sensitivity and high-throughput bio-chemical sensing.
作者
王朝钦
宋昊玥
杨熙
王艳琼
龚元
WANG Chaoqin;SONG Haoyue;YANG Xi;WANG Yanqiong;GONG Yuan(Key Laboratory of optical fiber sensing and communication(Ministry of education),University of Electronic Science and technology of China,Chengdu 611731,Sichuan,China;School of Information and Communication Engineering,University of Electronic Science and technology of China,Chengdu 611731,Sichuan,China)
出处
《应用科学学报》
CAS
CSCD
北大核心
2021年第5期809-820,共12页
Journal of Applied Sciences
基金
国家自然科学基金(No.61875034)
111计划(No.B14039)
四川省科技计划(No.2021YJ0101,No.2020107)资助。
关键词
微流激光
生化传感
增益介质
光学微腔
损耗
optofluidic laser
biochemical sensing
gain medium
optical microcavity
loss
