摘要
目的探讨在鼠神经生长因子(NGF)的基础上给予加味七味白术散治疗2型糖尿病(T2DM)合并糖尿病周围神经病变(DPN)的临床疗效,并评估患者的神经功能与神经传导速度。方法选取2017年6月~2019年9月我院收治的100例T2DM合并DPN的患者为研究对象,按照入组先后顺序分为对照组与观察组,两组各50例。对照组给予营养神经与控制血糖的基础性治疗,观察组在营养神经与控制血糖的基础上给予七味白术散治疗。所有的患者进行连续8周的治疗,在正中神经与腓总神经评估感觉(SNCV)及其运动(MNCV)神经传导速度,并采用多伦多临床评分系统(TCSS)评估神经功能,评估临床症状的恢复情况,最后记录临床疗效。同时测定所有患者的空腹血糖(FBG)、餐后2小时血糖(2 h PBG)的变化情况,血脂[低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)]的变化情况。结果对照组的治疗总有效率(81.25%)低于观察组(97.73%)(P<0.05);两组患者治疗后2 h PBG、FBG、TG、LDL-C、TC均低于治疗前(P<0.05),而HDL-C较治疗前升高(P<0.05),以上血糖血脂治疗后两组患者之间比较差异无统计学意义(P>0.05);治疗后,两组患者正中神经及其腓总神经的MNCV与SNCV均高于治疗前(P<0.05),且观察组高于对照组(P<0.05);治疗后两组患者TCSS评分及临床症状评分均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。结论在鼠神经生长因子的基础上给予加味七味白术散治疗能很好改善2型糖尿病合并糖尿病周围神经病变患者的临床症状、神经功能,提高临床疗效,可在临床推广应用。
Objective To research the clinical effect of rat nerve growth factor(NGF)combined with Jiawei Qiwei Baizhu powder in patients with diabetic peripheral neuropathy(DPN).Methods 100 patients with T2DM complicated with DPN treated in our hospital from June 2017 to September 2019 were selected as the research object.They were divided into control group and observation group according to the order of enrollment,with 50 cases in each group.The control group was given the basic treatment of nutritional nerve and blood glucose control,and the observation group was given Qiwei Baizhu powder on the basis of nutritional nerve and blood glucose control.All patients were treated for 8 weeks.Sensory(SNCV)and motor(MNCV)nerve conduction velocity were evaluated in the median nerve and common peroneal nerve.Neurological function was evaluated by Toronto clinical scoring system(TCSs),and the recovery of clinical symptoms was evaluated.Finally,the clinical efficacy was recorded.At the same time,the changes of fasting blood glucose(FBG),2-hour postprandial blood glucose(2H PBG)and blood lipid low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)and high density lipoprotein cholesterol(HDL-C)were measured.Results The total effective rate of the control group(81.25%)was lower than that of the observation group(97.73%)(P<0.05).At 2h after treatment,PBG,FBG,TG,LDL-C and TC in the two groups were lower than those before treatment(P<0.05),while HDL-C was higher than that before treatment(P<0.05).There was no significant difference in blood glucose and blood lipid between the two groups after treatment(P>0.05).After treatment,the MNCV and SNCV of median nerve and common peroneal nerve in the two groups were higher than those before treatment(P<0.05),and those in the observation group were higher than those in the control group(P<0.05).After treatment,the TCSs score and clinical symptom score of the two groups were lower than those before treatment(P<0.05),and the observation group was lower than that of the control group(P<0.05).Conclusion Adding Jiawei Qiwei Baizhu powder to the treatment of simple T2DM patients with DPN can increase the clinical effect and the neurological function.
作者
侯敏
陈巍
杨潇
谢婷
郭晓珊
HOU Min;CHEN Wei;YANG Xiao;XIE Ting;GUO Xiaoshan(The Second Affiliated Hospital,Liaoning University of Chinese Medicine, Shenyang 110034,China)
出处
《西部医学》
2021年第10期1486-1491,共6页
Medical Journal of West China
基金
辽宁省自然科学基金指导计划项目(2018011525-301)。
