摘要
肺癌是一种发病率高、死亡率高的恶性肿瘤,对人类健康构成极大威胁。新生血管生成可能是肺癌发生的重要机制之一。肺癌细胞的生长可通过新血管生成获得必要的营养物质,从而引起肺癌的扩散和转移。目前,抗血管生成靶向药是除手术、放化疗、免疫治疗外临床常用的西医治疗手段,然而治疗后会出现血栓、高血压、腹泻、心脏毒性等不良反应,严重影响了患者的生存质量。随着对血管生成的不断认知,肺癌治疗方案的选择成为肺癌治疗领域的研究热点和难点。中医学认为血管生成可归属于"络病"范畴,由于外邪入侵、正气不足等因素导致机体脏腑虚损,日久可致气机不畅,瘀血痰浊等互结于络道,使络脉功能下降,为肺癌的发生提供了有利条件。已有越来越多的现代研究证实中药可抑制肺癌新生血管生成,从而起到抑瘤作用。此外,由于中药具有独特的优势,可以有效降低不良反应,提高疗效,改善患者生活情况,配合其他西医疗法有明显的协同作用,在肺癌治疗中有广泛的应用前景。该文通过总结中药抗肺癌血管生成的相关实验研究结果,对中药抑制肺癌血管生成的作用机制进行了梳理,以期为临床肺癌治疗策略的优化提供借鉴和参考。
Lung cancer is a malignant tumor with high incidence and high mortality,posing a great threat to human health. Neovascularization may be one of the important mechanisms of lung cancer. The growing lung cancer cells can obtain necessary nutrients from the newly formed blood vessels,thereby causing the spread and metastasis of lung cancer. Nowadays,anti-angiogenic drugs are commonly used in western medicine in addition to surgery,radiotherapy,chemotherapy,and immunotherapy. However,the resulting adverse reactions such as thrombosis,hypertension,diarrhea,and cardiotoxicity have seriously affected the quality of life of patients. As the recognition of angiogenesis deepens,the selection of lung cancer treatment options has become a research hotspot and difficulty in the field of lung cancer treatment. In traditional Chinese medicine(TCM),angiogenesis is believed to fall into the category of"collateral disease". The invasion of external pathogens and deficiency of healthy Qi will cause visceral dysfunction,which can be gradually followed by Qi obstruction and blood stasis and phlegm-turbidity congesting the collaterals. As a result,the collateral function will be damaged,providing favorable conditions for the occurrence of lung cancer. More and more modern studies have confirmed that TCM is able to inhibit angiogenesis in the lung cancer,thereby resisting the tumor. In addition,by virtue of the unique advantages,TCM effectively reduces adverse reactions,enhances the efficacy,and improves the living conditions of patients. Moreover,it can synergize with other western medicine therapies in the treatment of lung cancer,exhibiting a wide application prospect. This paper summarizes the mechanisms of TCM in inhibiting angiogenesis of lung cancer reported in relevant experimental research,hoping to provide reference for the optimization of clinical treatment strategies for lung cancer.
作者
赵丽娜
李倩
王闻文
杨胤清
肖桦
ZHAO Li-na;LI Qian;WANG Wen-wen;YANG Yin-qing;XIAO Hua(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第20期236-243,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
四川省中医药管理局科学技术研究专项(2020JC0030)。
关键词
肺癌
血管生成
中药
作用机制
lung cancer
angiogenesis
traditional Chinese medicine
mechanism of action
