摘要
Ubiquitously distributed microorganisms are natural decomposers of environmental pollutants.However,because of continuous generation of novel recalcitrant pollutants due to human activities,it is difficult,if not impossible,for microbes to acquire novel degradation mechanisms through natural evolution.Synthetic biology provides tools to engineer,transform or even re-synthesize an organism purposefully,accelerating transition from unable to able,inefficient to efficient degradation of given pollutants,and therefore,providing new solutions for environmental bioremediation.In this review,we described the pipeline to build chassis cells for the treatment of aromatic pollutants,and presented a proposal to design microbes with emphasis on the strategies applied to modify the target organism at different level.Finally,we discussed challenges and opportunities for future research in this field.
基金
supported by grants from the National Natural Science Foundation of China(31971347,32030004 and 31725002)
Shenzhen Science and Technology Program(KQTD20180413181837372)
Guangdong Provincial Key Laboratory of Synthetic Genomics(2019B030301006)
Shenzhen Outstanding Talents Training Fund.
