摘要
目的探讨子宫肌瘤剔除术前应用低剂量米非司酮的效果及对血清性激素水平的影响。方法选择南阳市宛城区第一人民医院2020年1—6月收治的95例子宫肌瘤患者为研究对象,按照随机数字表法将患者分为观察组(48例)和对照组(47例)。术前给予对照组常规剂量的米非司酮,术前给予观察组低剂量米非司酮,治疗2个月后,比较两组患者的肿瘤直径、手术时间、术中出血量、各项血清性激素[卵泡刺激素(FSH)、孕激素(P)、黄体生成素(LH)及雌二醇(E_(2))]及生活质量评分。结果治疗后,两组肿瘤直径均缩小,且观察组较对照组小(P<0.05)。治疗后,两组患者接受子宫肌瘤剔除术,观察组手术时间较对照组短(P<0.05);两组患者术中出血量比较,差异无统计学意义(P>0.05)。治疗后,两组血清FSH、P、LH、E_(2)水平均下降,且观察组低于对照组(P<0.05)。治疗后,两组躯体功能、认知功能、情绪功能、社会角色功能评分均升高,且观察组较对照组高(P<0.05)。结论子宫肌瘤剔除术前采用低剂量米非司酮对缩小肿瘤的效果优于常规剂量,能够有效缩短手术时间,改善血清性激素水平,提高患者生活质量。
Objective To investigate the effect of low-dose mifepristone before uterine fibroids removal and its effect on serum sex hormone levels.Methods The ninety-five patients with uterine fibroids admitted in the First People’s Hospital of Wancheng District in Nanyang from January to June 2020 were selected as the study subjects,and they were divided into two groups according to the random number table method,with 48 cases in observation group and 47 cases in control group.The control group was given conventional doses of mifepristone before surgery,and the observation group was given low doses of mifepristone before surgery.After 2 months of treatment,the tumor diameter,operation time,intraoperative blooding,serum sex hormone levels[follicle stimulating hormone(FSH),progesterone(P),luteinizing hormone(LH)and estradiol(E_(2))]and quality of life score in the two groups were compared.Results After treatment,the tumor diameters of the two groups were reduced,and the tumor diameter in observation group was smaller than that in control group(P<0.05).After treatment,both groups of patients underwent uterine myomectomy,and the operation time of observation group was shorter than that of control group(P<0.05).There was no statistical difference in intraoperative blooding between the two groups(P>0.05).After treatment,the levels of FSH,P,LH and E_(2) in serum decreased in the two groups,and the above indicators in observation group were lower than those in control group(P<0.05).After treatment,somatic,cognitive,emotional and social role function scores were increased in both groups,and the scores of the observation group were higher than those of the control group(P<0.05).Conclusion The effect of using low-dose mifepristone before surgery on tumor shrinkage is significantly better than that of conventional doses.It can effectively shorten the operation time,improve the level of serum sex hormones and quality of life.
作者
茹珺
RU Jun(Department of Obstetrics and Gynecology,the First People’s Hospital of Wancheng District in Nanyang,Nanyang 473001,China)
出处
《河南医学研究》
CAS
2021年第30期5691-5693,共3页
Henan Medical Research
