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Small P values may not yield robust findings:an example using REST-meta-PD 被引量:6

小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例
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摘要 Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].
作者 Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang 贾熙泽;赵娜;董昊铭;孙家伟;Marek Barton;Roxana Burciu;Nicolas Carrière;Antonio Cerasa;陈博宇;陈俊;Stephen Coombes;Luc Defebvre;Christine Delmaire;Kathy Dujardin;Fabrizio Esposito;范国光;Federica Di Nardo;冯怡萱;Brett W.Fling;Saurabh Garg;Moran Gilat;Martin Gorges;Shu-Leong Ho;Fay B.Horak;胡晓;胡晓飞;黄飚;黄沛钰;贾泽娟;Christina Jones;Jan Kassubek;Lenka Krajcovicova;Ajay Kurani;李静;李晴;刘爱萍;刘波;刘虎;刘卫国;Renaud Lopes;娄毓婷;罗巍;Tara Madhyastha;毛妮妮;Grainne McAlonan;Martin J.McKeown;Shirley Pang;Andrea Quattrone;Irena Rektorova;Alessia Sarica;商慧芳;James M.Shine;Priyank Shukla;Tomas Slavicek;宋潇鹏;Gioacchino Tedeschi;Alessandro Tessitore;David Vaillancourt;王健;王珏;Z.Jane Wang;魏鲁庆;邬霞;徐晓俊;闫磊;杨靓;杨万群;姚乃琳;张得龙;张久权;张敏鸣;张艳玲;周彩红;严超赣;左西年;Mark Hallett;吴涛;臧玉峰(Center for Cognition and Brain Disorders,the Affiliated Hospital,Hangzhou Normal University,Hangzhou 310015,China;Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments,Hangzhou 311121,China;National Basic Science Data Center,Beijing 100190,China;State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research,Beijing Normal University,Beijing 100875,China;School of Information and Electronics Technology,Jiamusi University,Jiamusi 154007,China;Neuroscience Program,Central European Institute of Technology,CEITEC,Masaryk University,Brno 62500,Czech Republic;Department of Applied Physiology and Kinesiology,University of Florida,Gainesville FL 32611,USA;Univ.Lille,Inserm,CHU Lille,U1172-LilNCog-Lille Neuroscience&Cognition,Lille F-59000,France;The Institute for Biomedical Research and Innovation,National Research Council,Mangone CS 87050,Italy;Department of Radiology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China;Department of Radiology,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China;Department of Medicine,Surgery and Dentistry,Scuola Medica Salernitana,University of Salerno,Fisciano,SA 132-84084,Italy;Department of Advanced Medical and Surgery Sciences,University of Campania“Luigi Vanvitelli”,Caserta 81100,Italy;Eye Center of the 2nd Affiliated Hospital,Medical College of Zhejiang University,Hangzhou 310020,China;Zhejiang Provincial Key Lab of Ophthalmology,Hangzhou 310020,China;Department of Health and Exercise Science,Colorado State University,Fort Collins CO 80523,USA;Pacific Parkinson’s Research Centre,University of British Columbia,Vancouver BC V6E 2M6,Canada;Department of Medicine(Neurology)University of British Columbia,Vancouver BC V6T 1B7,Canada;Brain and Mind Center,The University of Sydney,Sydney NSW 2006,Australia;Department of Neurology,Ulm University,Ulm 89081,Germany;Division of Neurology,Department of Medicine,Queen Mary Hospital,University of Hong Kong,Hong Kong 999077,China;Department of Neurology,School of Medicine,Oregon Health&Science University,Oregon 97239-3098,USA;VA Portland Health Care System,Portland OR 97239,USA;Department of Radiology,The Affiliated Brain Hospital with Nanjing Medical University,Nanjing 210029,China;Department of Radiology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;Department of Radiology,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Department of Radiology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Graduate School of Hebei Medical University,Shijiazhuang 50017,China;Department of Neurology,Northwestern University Feinberg School of Medicine,Chicago IL 60611,USA;Department of Neurology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;College of Information Science and Technology,Beijing Normal University,Beijing 100875,China;Department of Electrical and Computer Engineering,University of British Columbia,Vancouver BC V6T 1Z4,Canada;Department of Neurology,The Affiliated Brain Hospital With Nanjing Medical University,Nanjing 210029,China;Department of Paediatrics,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Neurology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Radiology,University of Washington,Seattle WA 98195-7117,USA;South London and Maudsley NHS Foundation Trust,London BR33BX,UK;State Key Laboratory for Cognitive Sciences,The University of Hong Kong,Hong Kong 999077,China;Department of Forensic and Neurodevelopmental Science,Institute of Psychiatry,King’s College London,London WC2R 2LS,UK;Institute of Neurology,University Magna Graecia of Catanzaro,Catanzaro CZ 88100,Italy;Neuroscience Center,Department of Medical and Surgical Sciences,Magna Graecia University of Catanzaro,Catanzaro CZ 88100,Italy;Department of Neurology,West China Hospital,Sichuan University,Chengdu 610065,China;The Mind Research Network,Albuquerque NM 87106,USA;School of Sports Medicine and Health,Chengdu Sport University,Chengdu 610041,China;Department of Psychiatry,Queen Mary Hospital,The University of Hong Kong,Hong Kong 999077,China;Human Motor Control Section,National Institute of Neurological Disorders and Stroke,National Institutes of Health,Bethesda MD 20892,USA;Department of Neurobiology,Neurology and Geriatrics,Xuanwu Hospital of Capital Medical University,Beijing Institute of Geriatrics,Beijing 100053,China;Clinical Center for Parkinson’s Disease,Capital Medical University,Beijing 100069,China;Beijing Key Laboratory for Parkinson’s Disease,Parkinson Disease Center of Beijing Institute for Brain Disorders,Beijing 100050,China;National Clinical Research Center for Geriatric Disorders,Beijing 100730,China)
机构地区 Center for Cognition and Brain Disorders Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments National Basic Science Data Center State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research School of Information and Electronics Technology Neuroscience Program Department of Applied Physiology and Kinesiology Univ.Lille The Institute for Biomedical Research and Innovation Department of Radiology Department of Radiology Department of Medicine Department of Advanced Medical and Surgery Sciences Eye Center of the Zhejiang Provincial Key Lab of Ophthalmology Department of Health and Exercise Science Pacific Parkinson’s Research Centre Department of Medicine(Neurology)University of British Columbia Brain and Mind Center Department of Neurology Division of Neurology Department of Neurology VA Portland Health Care System Department of Radiology Department of Radiology Department of Radiology Department of Radiology Graduate School of Hebei Medical University Department of Neurology Department of Neurology College of Information Science and Technology Department of Electrical and Computer Engineering Department of Neurology Department of Paediatrics Department of Neurology Department of Radiology South London and Maudsley NHS Foundation Trust State Key Laboratory for Cognitive Sciences Department of Forensic and Neurodevelopmental Science Institute of Neurology Neuroscience Center Department of Neurology The Mind Research Network School of Sports Medicine and Health Department of Psychiatry Human Motor Control Section Department of Neurobiology Clinical Center for Parkinson’s Disease Beijing Key Laboratory for Parkinson’s Disease National Clinical Research Center for Geriatric Disorders
出处 《Science Bulletin》 SCIE EI CSCD 2021年第21期2148-2152,M0003,共6页 科学通报(英文版)
基金 the National Natural Science Foundation of China(81520108016,81661148045,and 31471084 to Yu-Feng Zang 81671774 and 81630031 to Chao-Gan Yan 81571228 to Tao Wu 61571047 to Xia Wu 81701664 to Jian Wang,81471654 to Biao Huang 81701671 to Wei-Guo Liu 82001898 to Xi-Ze Jia 81771820,81371519 and 81571654 to Wei Luo) Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang,BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan,NIH(2R01AG006457 to Fay B.Horak 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha) NINDS Intramural Research Program to Mark Hallett Start-up Funds for Leading Talents at Beijing Normal University National Basic Science Data Center‘‘Chinese Data-sharing Warehouse for In-vivo Imaging Brain”(NBSDC-DB-15)to Xi-Nian Zuo Grant NU20-04-00294 of the Agency for Health Research,Czech Republic to Lenka Krajcovicova and Irena Rektorova。
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