摘要
目的研究左心结构异常与血浆氨基末端B型钠尿肽原(NT-proBNP)在射血分数保留的心力衰竭(HFpEF)患者的相关性。方法选取2020年1月至2021年1月惠州市第六人民医院收治的80例HFpEF患者,入组患者随机分组不分性别,均通过超声测量,将患者进行按照检查结果进行分组。第1组:心功能Ⅰ级伴左心结构异常组,25例;第2组:心功能Ⅱ级伴左心结构异常组,35例;第3组:心功能Ⅲ级及Ⅲ级以上伴左心结构异常组,20例。对患者均进行血浆NT-proBNP水平检测,对比检查指标差异。结果3组患者轻度增大、中度增大、重度增大发生率比较差异有统计学意义(P<0.05);3组患者左房内径(LAD)、左室舒张末期后壁厚度(LVPWTd)、左室舒张末期内径(LVEDd)差异有统计学意义(P<0.05),左室收缩末期内径(LVESd)、E峰减速时间(DT)差异无统计学意义(P>0.05);3组患者血浆NT-proBNP水平、二尖瓣环舒张早期运动峰速度(Em)、二尖瓣舒张早期血流峰速度E与二尖瓣环舒张早期运动峰速度比值(E/Em)差异有统计学意义(P<0.05),二尖瓣舒张早期血流峰速度E与晚期血流峰速度A比值(E/A)差异无统计学意义(P>0.05)。结论HFpEF患者可出现左心结构明显异常及血浆NT-proBNP升高。同时测量血浆NT-proBNP指标,并进行心功能各指标的检测,两者之间的联系较为密切,可用于进行疾病判断。
【Objective】To study the correlation between left ventricular structural abnormalities and plasma NT-proBNP in patients with ejection fraction preserved heart failure.【Methods】Eighty patients with ejection fraction preserved heart failure in Huizhou Sixth People's Hospital from January 2020 to January 2021 were selected.The patients were randomly divided into two groups regardless of gender.The patients were divided into groups according to the examination results through ultrasonic measurement.Group 1:cardiac function grade I with abnormal left ventricular structure(n=25);group 2:cardiac function grade II with abnormal left ventricular structure(n=35);group 3:cardiac function grade III and above with abnormal left ventricular structure(n=20).The plasma NT-proBNP level was detected and the difference of indexes was compared.【Results】There was significant difference in the incidence of mild,moderate,and severe enlargement among the three groups(P<0.05).The difference in LAD,LVPWTd,LVEDd among the three groups was statistically significant(P<0.05),but there was no significant difference in LVESd and DT among the three groups(P>0.05).There were significant differences in plasma NT-proBNP,EM and E/EM among the three groups(P<0.05).There was no difference in E/A among the three groups(P>0.05).【Conclusion】There is a close relationship between left ventricular structural abnormality and plasma NT-proBNP in patients with ejection fraction preserved heart failure and cardiac function.
作者
林佩环
刘远友
观春媚
LIN Peihuan;LIU Yuanyou;GUAN Chunmei(Internal Medicine-Cardiovascular Department,the Sixth People's Hospital of Huizhou City,Huizhou,Guangdong 516211,China;the Occupational Disease Prevention and Treatment Institute of Huizhou City(Huizhou Tuberculosis Prevention Institute),Huizhou,Guangdong 516001,China)
出处
《中国医学工程》
2021年第10期84-87,共4页
China Medical Engineering
