摘要
目的系统评价匹伐他汀对新发糖尿病是否有影响。方法查阅中国知网、万方数据库、pubmed、web of science、Elsevier ScienceDirect Online,检索时间从建库到2021年5月期间公开发表的所有关于匹伐他汀和新发糖尿病之间关系的文章。检索关键词为pitavastatin、new onset、diabetes mellitus。收集有关匹伐他汀与其他他汀类药物治疗血脂异常期间新发糖尿病病例比较的随机对照研究。对论文中接受匹伐他汀治疗的研究组和接受其他他汀类药物治疗或空白的对照组进行Meta分析。然后观察纳入研究的两组之间的新发糖尿病的差别,采用RevMan5.1统计学软件对其进行Meta分析。结果研究共纳入5项随机对照,110212例患者,试验组匹伐他汀对新发糖尿病的影响与对照组其他他汀类药物差异无统计学意义(P>0.05)。但匹伐他汀与空白对照相比差异有统计学意义(P<0.05)。结论他汀类药物增加新发糖尿病风险应该是类效应,匹伐他汀对病人血糖的控制并没有明显优势。
Objective To systematically evaluate whether pitavastatin has an effect on new-onset diabetes.Methods The CNKI,Wanfang database,pubmed,web of science,and Elsevier ScienceDirect Online were searched,and all articles on the relationship between pitavastatin and new-onset diabetes were retrieved from the establishment of the database to May 2021.The search keywords are pitavastatin,new onset,and diabetes mellitus.To collect randomized controlled trials comparing pitavastatin and other statins in the treatment of dyslipidemia in new cases of diabetes.Meta-analysis was performed on the study group receiving pitavastatin treatment and the control group receiving other statin treatment or blank in the paper.Then observe the difference of new-onset diabetes between the two groups in the papers included in the study,and use RevMan5.1 statistical software to conduct Meta analysis on it.Results The study included 5 randomized controlled trials with 110212 patients.The effect of pitavastatin in the study group on new-onset diabetes was not significantly different from other statins in the control group(P>0.05).However,there was a statistically significant difference between Pitavastatin and the blank control(P<0.05).Conclusion Statins increase the risk of new-onset diabetes should be a similar effect,and pitavastatin has no obvious advantage in the control of patients'blood glucose.
作者
刘星雨
怀文娟
李琳琳
陈诚
LIU Xingyu;HUAI Wenjuan;LI Linlin;CHEN Cheng(Department of Pharmacy,Civil Aviation Shanghai Hospital,Shanghai,200336 China)
出处
《糖尿病新世界》
2021年第16期97-100,共4页
Diabetes New World Magazine
