摘要
目的:研究瞿麦的化学成分。方法:利用硅胶、Sephadex LH⁃20葡聚糖凝胶、ODS、MPLC等柱色谱方法进行化合物的分离纯化,根据化合物的理化性质、波谱方法进行结构鉴定。结果:从瞿麦醇提物的二氯甲烷部位中分离得到14个化合物,分别鉴定为:(+)⁃表松脂醇(1)、松脂醇(2)、邻苯二甲酸二丁酯(3)、(3Z,6Z,9Z)⁃3,6,9⁃nonadecatriene(4)、儿茶酚(5)、脱氢地芰普内酯(6)、金色酰胺醇酯(7)、皂皮酸(8)、去氢吐叶醇(9)、琥珀酸(10)、melrubiellin A(11)、melrubiellin B(12)、水杨酸(13)、青刺尖木脂醇(14)。结论:其中,化合物1~4、6~12、14为首次从瞿麦中分离得到。
Objective:To study the chemical constituents from the stems and leaves of Dianthus superbus.Methods:The compounds were isolated and purified by silica gel,Sephadex LH⁃20,ODS,MPLC and other column chromatography methods.The structures were i⁃dentified by physicochemical properties and spectroscopic methods.Results:Fourteen compounds were isolated from dichloromethane ex⁃tract of ethanol extract of Dianthus superbus,and identified as(+)⁃epipinoresinol(1),pinoresinol(2),dibutyl phthalate(3),(3Z,6Z,9Z)⁃3,6,9⁃nonadecatriene(4),catechol(5),dehydrololiolide(6),aurantiamide acetate(7),quillaic acid(8),dehydrovomifoliol(9),succinic acid(10),melrubiellin A(11),melrubiellin B(12),salicylic acid(13),prinsepiol(14),respectively.Conclusion:Among them,compounds 1 to 4,6 to 12,14 are isolated from the stems and leaves of Dianthus superbus for the first time.
作者
洪玲洁
袁铭铭
李俊
邹传生
周国平
HONG Ling-jie;YUAN Ming-ming;LI Jun;ZOU Chuan-sheng;ZHOU Guo-ping(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Jiangxi Center for Drug Certification and Evalua-tion,Nanchang 330046,China;Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China)
出处
《中药材》
CAS
北大核心
2020年第12期2933-2937,共5页
Journal of Chinese Medicinal Materials
基金
江西省重点研发计划项目(20171BBG70104)。
关键词
瞿麦
石竹科
化学成分
青刺尖木脂醇
Dianthus superbus L.
Caryophyllaceae
Chemical constituents
Prinsepiol
