摘要
Oxygen,iron,and polyunsaturated fatty acids(PUFAs;fatty acids containing more than one double bond)are all beneficial to our cellular lives.Incorporation of these components into cellular processes,however,comes at a cost:the bis-allylic structure of PUFAs and the enrichment of cellular environments with iron and oxygen render PUFA-containing phospholipids(PUFA-PLs)particularly susceptible to peroxidation(Yang and Stockwell,2016).
基金
Research in the authors'lab has been supported by The University of Texas MD Anderson Cancer Center,National Institutes of Health grants R01CA181196,R01CA190370,R01CA244144,and R01CA247992(to BG)
a CPRIT Research Training Grant(RP170067)
the Dr.John J.Kopchick Research Award from The Un iversity of Texas MD Anders on Cancer Center UTHealth Graduate School of Biomedical Sciences(to PK)
This work was also supported in part by Cancer Center Support(Core)Grant P30 CA016672 from the National Cancer Institute,to The University of Texas MD Anderson Cancer Center.
