摘要
目的探讨盆腔超声单指标及多指标联合对女童中枢性性早熟(CPP)的诊断价值。方法选取CPP女童205例(CPP组)和同期体检的健康女童221例(对照组),均行盆腔超声检查,比较两组子宫、卵巢各指标的差异;绘制受试者工作特征曲线,选取曲线下面积(AUC)值高的超声指标,建立二元Logistic回归模型,得到联合超声指标Y,比较超声单指标与联合指标Y对CPP的诊断效能。结果CPP组子宫体积、卵巢体积、较大卵泡直径、卵泡个数、内膜厚度均较对照组增加,差异均有统计学意义(均P<0.05)。ROC曲线分析结果显示,卵巢体积诊断CPP的AUC为0.82,截断值为1.16 ml时,特异性为72.50%,敏感性为82.20%;子宫体积诊断CPP的AUC为0.79,截断值为1.66 ml时,特异性为71.30%,敏感性为61.20%。联合子宫体积、卵巢体积和内膜厚度得到的联合超声指标Y对CPP的诊断价值均高于超声单指标(均P<0.05),其AUC为0.97,截断值为0.90时,特异性为97.20%,敏感性为85.19%。结论超声指标联合应用能进一步提高盆腔超声对CPP的诊断准确率,有重要的临床应用价值。
Objective To explore the diagnostic value of pelvic ultrasound with single index and combined index for central precocious puberty(CPP)in girls.Methods A total of 205 CPP girls(CPP group)and 221 healthy girls(control group)underwent physical examination during the same period were enrolled.Pelvic ultrasound examination was performed to compare the sizes of the uterus and ovaries between the two groups.The receiver operating characteristic curve was drawn,and the high area value under the curve(AUC)was selected to establish a binary Logistic regression model to obtain the combined ultrasound index Y.The diagnostic efficacy of the ultrasonic single index and the combined index for CPP was compared.Results Compared with control group,the uterine volume,ovarian volume,larger follicle diameter,number of follicles,and endometrial thickness in the CPP group were increased,the difference were statistically significant(all P<0.05).The ROC curve analysis results showed that the AUC for the diagnosis of CPP by ovarian volume was 0.82,the cut-off value was 1.16 ml,the specificity was 72.50%,and the sensitivity was 82.20%.The AUC for the diagnosis of CPP by uterine volume was 0.79,the cut�off value was 1.66 ml,the specificity was 71.30%,and the sensitivity was 61.20%.The diagnostic value of the combined ultrasonic index Y obtained by uterine volume,ovarian volume and endometrial thickness for CPP was higher than that of single ultrasonic index(all P<0.05),with an AUC of 0.97,a cut-off value of 0.90,a specificity of 97.20%,and a sensitivity of 85.19%.Conclusion The combination of ultrasonic indicators can further improve the diagnostic accuracy of pelvic ultrasound in children with CPP,which has important clinical application value.
作者
袁小涵
何丽红
刘赟
向星月
查晓霞
YUAN Xiaohan;HE Lihong;LIU Yun;XIANG Xingyue;ZHA Xiaoxia(Department of Ultrasound,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《临床超声医学杂志》
CSCD
2021年第10期769-772,共4页
Journal of Clinical Ultrasound in Medicine
基金
雅安市科学技术局项目(2020yyjskf04)。
关键词
超声检查
性早熟
中枢性
儿童
Ultrasonography
Precocious puberty,central
Children
