摘要
目的分析IgA肾病(IgAN)合并高血压患者的临床特征及预后。方法选取我院收治的IgAN患者180例,根据是否合并高血压分为IgAN组和高血压组,各90例。比较两组的临床资料、肾脏损害情况和实验室指标。使用Spearman分析高血压组高血压分级与肾脏损害情况、实验室指标的相关性。使用Kaplan-Meier比较两组的无终点事件生存时间。结果高血压组的血尿发生率、收缩压、舒张压均明显高于IgAN组,IgAN病程明显长于IgAN组(P<0.05);两组的Lee氏标准分级比较,差异具有统计学意义(P<0.05)。高血压组的间质指数、小球指数、血管指数、血尿酸水平、24 h尿蛋白定量均明显高于IgAN组(P<0.05)。高血压组高血压分级与间质指数、小球指数、血管指数、血尿酸、24 h尿蛋白定量均呈正相关(P<0.05)。高血压组的无终点事件生存时间明显短于IgAN组(P<0.05)。结论IgAN合并高血压患者的肾脏损害情况、血尿酸、尿蛋白水平均明显高于非高血压IgAN患者,并与高血压分级呈明显正相关,且预后更差。
Objective To analyze the clinical characteristics and prognosis of patients with IgA nephropathy(IgAN)complicated with hypertension.Methods A total of 180 IgAN patients admitted in our hospital were selected and divided into IgAN group and hypertension group according to whether they were complicated with hypertension,with 90 cases in each group.The clinical data,kidney damage and laboratory indicators of the two groups were compared.Spearman was used to analyze the correlation between hypertension classification and kidney damage and laboratory indicators in the hypertension group.Kaplan-Meier was used to compare the survival time of end-free events between the two groups.Results The incidence of hematuria,systolic blood pressure and diastolic blood pressure in the hypertension group were significantly higher than those in the IgAN group,and IgAN course was significantly longer than that in the IgAN group(P<0.05);the difference of Lee's standard grading between the two groups of was statistically significant(P<0.05).The interstitial index,glomerular index,vascular index,blood uric acid level and 24 h urine protein quantification in the hypertension group were significantly higher than those in the IgAN group(P<0.05).The hypertension classification of the hypertension group were positively correlated with interstitial index,glomerular index,vascular index,blood uric acid and 24 h urine protein quantification(P<0.05).The survival time of end-free events in the hypertension group was significantly shorter than that in the IgAN group(P<0.05).Conclusion The renal damage,blood uric acid and urine protein levels of IgAN patients with hypertension were significantly higher than those of non-hypertensive IgAN patients,which were significantly positively correlated with the hypertension classification.The prognosis of IgAN patients with hypertension are worse.
作者
党彦龙
徐玉祥
张媛
DANG Yanlong;XU Yuxiang;ZHANG Yuan(Nephrology Department,Xi'an XD Group Hospital,Xi'an 710077;Kidney Internal Medicine Department,Xi'an People'sHospital/Xi'an Fourth Hospital,Xi'an 710004,China)
出处
《临床医学研究与实践》
2021年第30期23-26,共4页
Clinical Research and Practice
基金
陕西省卫生计生科研基金项目(No.2016B005)。
关键词
IGA肾病
高血压
预后
IgA nephropathy
hypertension
prognosis
