摘要
考察12个喹唑啉衍生物的抗羊泰勒焦虫活性、对小鼠安全性和对家兔刺激性。取小鼠130只,随机分为12个衍生物组和1个对照组,12个喹唑啉衍生物组分别腹腔注射0.5 mL(1 mg/kg)相应衍生物,对照组注射生理盐水,注射后观察7 d;采用肌内注射法观察12个相应喹唑啉衍生物对家兔后腿肌肉的刺激性。选取羊泰勒焦虫自然病例,分别用12个化合物和三氮脒进行治疗,观察其临床治疗效果。安全性试验结果显示,12个喹唑啉衍生物1 mg/kg剂量对小鼠安全;对家兔后腿注射局部无刺激性。临床治疗结果显示,3个化合物对羊焦虫病有良好的治疗效果,与对照药物三氮脒效果相当。提示3个喹唑啉衍生物有望成为治疗羊泰勒焦虫病的有效药物。
The anti-sheep theileriosis activity of 12 quinazoline derivative was investigated and the safety to mice and irritation to rabbits was evaluated. The natural cases of sheep Theileria were selected,and 12 compounds and triamidine were used to treat the natural cases,and the clinical effect was observed. 130 mice were randomly divided into 12 treatment groups and a control group,and their safety were evaluated by intraperitoneally injecting with each corresponding quinazoline derivatives(1 mg·kg-1)for treatment groups and normal saline for control group,respectively. The irritation of 12 quinazoline derivatives on hind leg muscles of rabbits was observed by intramuscular injection. The results showed that three compounds had good therapeutic effects on sheep Theileria,which was equivalent to the control drug triadimidine. At the given dose,12 quinazoline derivatives were safe for mice. It has no local irritation to rabbit hind legs.
作者
苗小楼
尚小飞
代立霞
李冰
王瑜
张继瑜
王东升
潘虎
MIAO Xiaolou;SHANG Xiaofei;DAI Lixia;LI Bing;WANG Yu;ZHANG Jiyu;WANG Dongsheng;PAN Hu(Key Lab of New Animal Drug Project,Gansu Province,Engineering&Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province,Key Lab of Veterinary Pharmaceutics Discovery,Ministry of Agriculture and Rural Affairs,Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS,Lanzhou Gansu 730050,China)
出处
《中兽医医药杂志》
CAS
2021年第5期73-75,共3页
Journal of Traditional Chinese Veterinary Medicine
基金
甘肃省科技计划项目(18YF1NA128)。
关键词
喹唑啉
衍生物
羊焦虫病
鸡骨风
quinazoline
derivatives
caprine theileriosis
Radix Dichroae
