摘要
胎球蛋白B作为半胱氨酸蛋白酶抑制剂,在人类代谢疾病、炎症、肿瘤、生殖方面都扮演重要角色。糖脂代谢的紊乱与人体糖尿病、非酒精性脂肪肝等代谢疾病都密切相关。近年有大量关于胎球蛋白B与糖脂代谢的研究。本文旨在对目前的研究进展作一综述,以便更好地理解胎球蛋白B在糖脂代谢中的角色,为代谢疾病的预防、诊断及治疗提供一定思路。
Fetuin B,as a member of the cysteine protease inhibitors,was found to be a critical role in human metabolic disorders,inflammation,tumor and fertilization. The dysregulated of glucolipid metabolism is essentially associated with diabetes,non-alcoholic fatty liver disease and other metabolic disorders. Recent studies have shown that a relationship between fetuin B and glucolipid metabolism,the aim of this review is to summarize the development of the studies,better elucidate the physiological role of fetuin B,as well as provide the new conceptions on prevention,diagnosis,and therapy of metabolic disorders.
作者
张瑞
刘东方
Zhang Rui;Liu Dongfang(Department of Endocrinology and Metabolism,Second Affiliated Hospital of Chongqing Medical University)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2021年第9期1031-1034,共4页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81370467)
重庆市卫健委资助项目(编号:2016ZDXM011)
重庆市科委民生资助项目(编号:cstc2017shmsA130069)。
关键词
胎球蛋白B
糖脂代谢
代谢综合征
胰岛素抵抗
fetuin B
glucolipid metabolism
metabolic syndrome
insulin resistance
