摘要
目的探讨盐酸氮卓斯汀片联合丙酸氟替卡松治疗变应性鼻炎(AR)的临床价值。方法选择2020年3—12月在河南科技大学第一附属医院接受治疗的126例AR患者作为研究对象,按随机数表法分为两组,各63例。对照组服用盐酸氮卓斯汀片治疗,观察组在对照组基础上联合丙酸氟替卡松鼻喷雾剂治疗,两组均连续治疗8周。比较两组临床疗效,比较两组血清可溶性血管细胞黏附分子-1(sVCAM-1)、白细胞介素(IL)-4、IL-12水平,比较两组鼻腔最小横截面积(NMCA)、总鼻腔阻力(TNR)及治疗期间不良反应发生情况。结果治疗8周后,观察组临床疗效(95.24%)较对照组(82.54%)高(P<0.05)。观察组血清sVCAM-1、IL-4水平低于对照组(P<0.05),血清IL-12水平高于对照组(P<0.05),TNR低于对照组(P<0.05)。两组NMCA及不良反应发生率差异无统计学意义(P>0.05)。结论盐酸氮卓斯汀片联合丙酸氟替卡松能够有效提高AR疗效,缓解患者鼻通气障碍,减轻炎症反应。
Objective To investigate the clinical value of azelastine hydrochloride tablets combined with fluticasone propionate in the treatment of allergic rhinitis(AR).Methods A total of 126 AR patients who were treated in the First Affiliated Hospital of Henan University of Science and Technology from March to December 2020 were selected as the research objects,and were divided into two groups according to the random number table method,with 63 cases in each group.Control group was treated with azelastine hydrochloride tablets,and observation group was treated with fluticasone propionate nasal spray on the basis of control group.Both groups were treated continuously for 8 weeks.The clinical efficacy of the two groups was compared.The serum levels of soluble vascular cell adhesion molecule-1(sVCAM-1),interleukin(IL)-4 and IL-12 were compared between the two groups.The nasal minimum cross-sectional area(NMCA),total nasal resistance(TNR)and adverse reactions during treatment were compared between the two groups.Results After 8 weeks of treatment,the clinical efficacy of the observation group was higher than that of the control group(95.24%vs.82.54%,P<0.05).In observation group,serum sVCAM-1 and IL-4 levels were lower than those in control group(P<0.05),serum IL-12 level was higher than that in control group(P<0.05),and TNR was lower than that in control group(P<0.05).There was no statistical difference in the incidence of NMCA and adverse reactions between the two groups(P>0.05).Conclusion Azelastine hydrochloride tablets combined with fluticasone propionate could effectively improve the efficacy of AR,relieve patients’nasal ventilation disorders,and reduce inflammation.
作者
丁楠
李胜杰
杨殊
DING Nan;LI Shengjie;YANG Shu(Department of Otorhinolaryngology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Outpatient Department,Zhengzhou No.4 Retirement Center,Henan Military Command,Zhengzhou 450000,China;Department of General Medicine,Neixiang County People’s Hospital,Nanyang 474350,China)
出处
《河南医学研究》
CAS
2021年第31期5858-5861,共4页
Henan Medical Research
关键词
变应性鼻炎
盐酸氮卓斯汀片
丙酸氟替卡松
鼻腔阻力
allergic rhinitis
azelastine hydrochloride tablet
fluticasone propionate
nasal resistance
