摘要
目的:评价三氧自体血回输疗法(O3-AHT)治疗痛风的安全性和有效性。方法:检索PubMed,EmBase,Web of Science(WOS),The Cochrane Library,中国生物医学文献服务系统(CBM),维普(VIP),中国知网(CNKI)和万方数据知识服务平台(WanFang Data)。利用EndNote X8软件管理文献,由两名研究人员根据纳入、排除标准独立进行文献筛选,提取数据,采用Cochrane质量评估工具评估偏倚风险。利用RevMan 5.3软件进行统计分析。结果:共纳入6篇随机对照试验,共511例患者。Meta分析结果显示,O3-AHT联合药物治疗痛风患者的总有效率、改善痛风患者的疼痛状况优于单纯药物治疗,不良反应发生情况两组不具有统计学差异[RR=1.21,95%CI(1.06,1.38),P<0.05]、[MD=-1.11,95%CI(-2.15,-0.06),P<0.05]、[OR=0.89,95%CI(0.43,1.82),P>0.05];单纯O3-AHT治疗痛风的血尿酸水平降低和不良反应发生情况与药物治疗相比,差异不具有统计学意义[MD=-41.94,95%CI(-94.80,10.92),P>0.05]、[OR=0.43,95%CI(0.11,1.63),P>0.05]。结论:三氧自体血回输疗法联合药物治疗痛风具有显著的疗效,且未增加不良反应发生率。
Objective:To evaluate the safety and efficacy of trioxygen autologous blood transfusion(O3-AHT)for the treatment of gout.Methods:PubMed,EmBase,Web of Science(WOS),The Cochrane Library,CBM,VIP,CNKI and Wanfang Data were searched.EndNote X8 software was used to manage the literature.Two researchers independently screened the literature according to the inclusion and exclusion criteria,extracted the data,and assessed the risk of bias using the Cochrane quality assessment tool.Statistical analysis was performed using RevMan 5.3 software.Results:Six RCTs with a total number of 511 patients were included in the meta-analysis.Meta-analysis results showed that in terms of total effective rate and improvement of pain status of gout patients were better than that of drug therapy alone,and there was no statistical difference in the incidence of adverse events between the two groups[RR=1.21,95%CI(1.06,1.38),P<0.05],[MD=-1.11,95%CI(-2.15,-0.06),P<0.05,P<0.05],[OR=0.89,95%CI(0.43,1.82),P>0.05],compared with drug therapy,there was no statistical significance in BUA reduction and adverse events occurrence in O3-AHT treatment of gout[MD=-41.94,95%CI(-94.80,10.92),P>0.05],[OR=0.43,95%CI(0.11,1.63),P>0.05].Conclusion:O3-AHT combined with drugs therapy has significant curative effect on gout and cannot promote incident rate of adverse reaction.
作者
冯鹿方
陈楠
李秀霞
李美萱
储夏静
李洁韵
李艳飞
马玉鑫
杨欣怡
白飞
王世中
刘兴荣
杨克虎
FENG Lu-fang;CHEN Nan;LI Xiu-xia;LI Mei-xuan;CHU Xia-jing;LI Jie-yun;LI Yan-fei;MA Yu-xin;YANG Xin-yi;BAI Fei;WANG Shi-zhong;LIU Xing-rong;YANG Ke-hu(Health Technology Assessment Center,Evidence-Based Social Science Research Center,School of Public Health,Lanzhou University,Gansu Lanzhou 730000,China;Evidence-Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Gansu Lanzhou 730000,China;Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province,Gansu Lanzhou 730000,China;National Center for Medical Service Administration,National Health Commission of the People′s Republic of China,Beijing,100086,China;Wuwei People′s Hospital,Gansu Wuwei,733000,China)
出处
《中国药物评价》
2021年第5期425-430,共6页
Chinese Journal of Drug Evaluation
基金
中央高校基本科研业务费专项资金(项目名称:循证科学研究交叉创新团队,项目编号:lzujbky-2021-ct06
项目名称:中药基因研究现状及其数据库的研发,项目编号:lzujbky-2021-kb22)。
关键词
三氧自体血回输疗法
痛风
有效性
安全性
系统评价
Trioxide-autotransfusion therapy
Gout
Effectiveness
Safety
Systematic review
