摘要
目的研究检测血清和尿液8-羟基脱氧鸟苷(8-hydroxydeoxyguanosine,8-OHdG)对稽留流产患者的评价作用并予以分析,为临床稽留流产的防治提供新的靶点与思路。方法收集深圳市福田区妇幼保健院妇科2019年3月至2020年2月收治的50例稽留流产患者作为观察组。另取同期于该院正常早孕要求终止妊娠孕妇50例作为对照组。分别采集两组的尿液及血清标本,检测并对比血清及尿液8-OHdG水平。此外,比较两组基线资料,以多因素Logistic回归分析稽留流产发生与各项因素的关系。结果观察组血清及尿液8-OHdG水平均高于对照组(P<0.05);观察组多次流产史、接触有毒物质史、吸烟及孕期服药人数占比均高于对照组(P<0.05);两组在年龄、饮酒及暴露于电脑/手机等辐射等方面比较,差异无统计学意义(P>0.05)。以稽留流产为因变量,以血清、尿液8-OHdG及多次流产史、接触有毒物质史、吸烟、孕期服药为自变量,赋值如下:血清、尿液8-OHdG均为原值输入;多次流产史、接触有毒物质史、吸烟、孕期服药均以是=1,否=0。经多因素Logistic回归分析发现,血清、尿液8-OHdG水平高表达以及多次流产史、接触有毒物质史、吸烟、孕期服药均是稽留流产发生的独立危险因素(P<0.05)。结论8-OHdG于稽留流产患者血清和尿液中均存在明显高表达,可作为临床稽留流产患者防治的潜在靶点。
Objective To study the evaluation effect of serum and urine 8-hydroxydeoxyguanosine(8-OHdG)on patients with missed abortion,so as to provide a new target and idea for the prevention and treatment of missed abortion.Methods A total of 50 hospitalized abortion patients admitted to the Department of Gynecology,Futian District Maternal and Child Health Care Hospital of Shenzhen City from March 2019 to February 2020 were selected as the observation group.In addition,50 pregnant women with normal early pregnancy requiring termination of pregnancy in our hospital during the same period were selected as the control group.Urine and serum samples were collected from the two groups,and the serum and urine levels of 8-OHdG were measured and compared.The baseline data of the two groups were compared,and the relationship between the occurrence of missed abortion and various factors was analyzed by multivariate Logistic regression.Results The serum and urine levels of 8-OHdG in the observation group were higher than those in the control group(P<0.05).The proportion of patients in the observation group with multiple abortion history,toxic substance exposure history,smoking and taking medication during pregnancy were higher than those in the control group(P<0.05).There were no statistically significant differences between the two groups in terms of age,alcohol consumption and exposure to radiation such as computer/mobile phone(P>0.05).With missed abortion as the dependent variable,serum and urine 8-OHdG,history of multiple abortions,exposure to toxic substances,smoking,and medication during pregnancy as the independent variables,were assigned as follows:serum and urine 8-OHdG were input as the original value;history of multiple miscarriages,exposure to toxic substances,smoking,and taking medication during pregnancy:yes=1,no=0.Multivariate Logistic regression analysis showed that high expression of 8-OHdG in serum and urine,history of multiple miscarriage,exposure to toxic substances,smoking,and medication during pregnancy were independent risk factors for miscarriage(P<0.05).Conclusion 8-OHdG is highly expressed in serum and urine of patients with missed abortion and may be a potential target for the prevention and treatment of missed abortion.
作者
钟苏云
周燕妮
Zhong Suyun;Zhou Yanni(Department of Gynecology,Futian Maternal and Child Health Hospital,Shenzhen Guangdong 518045,P.R.China)
出处
《中国计划生育和妇产科》
2021年第10期67-70,共4页
Chinese Journal of Family Planning & Gynecotokology
基金
2019年福田区公益性科研课题立项(项目编号:FTWS2019032)。
