摘要
目的:探讨喹硫平联合丙戊酸镁缓释片对双相情感障碍躁狂急性发作患者血清脑源性神经营养因子(BDNF)、胶质细胞源性神经营养因子(GDNF)及炎性因子水平的影响。方法:将80例双相情感障碍躁狂发作患者随机分为喹硫平联合丙戊酸镁治疗组(观察组,n=40)和丙戊酸镁治疗组(对照组,n=40)。连续治疗8周后,采用倍克-拉范森躁狂量表(BRMS)评估治疗效果,采用酶联免疫吸附试验(ELISA)测定两组血清BDNF、GDNF、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)水平。结果:治疗8周后,观察组BRMS评分低于对照组(P<0.05),而临床总有效率高于对照组(95.00%vs.80.00%,P<0.05);治疗8周后,观察组血清BDNF、GDNF水平高于对照组(P<0.05),但血清TNF-α、IL-1β水平低于对照组(P<0.05);两组治疗后血清IL-10水平,嗜睡、便秘、头晕、口感以及食欲减退等不良反应发生率及总发生率比较,差异均无统计学意义(P>0.05)。结论:双相情感障碍躁狂发作患者在接受丙戊酸镁缓释片治疗的基础上联合喹硫平可有效提高治疗效果,改善血清BDNF、GDNF及炎性因子水平,且未增加不良反应的发生风险。
Objective:To investigate the effect of quetiapine combined with magnesium valproate sustained-release tablets on the serum levels of brain-derived neurotrophic factor(BDNF),glial cell-derived neurotrophic factor(GDNF)and inflammatory factors in patients with manic episode of bipolar disorder.Methods:80 patients with bipolar disorder were randomly divided into magnesium valproate treatment group(control group,n=40)and quetiapine combined with magnesium valproate treatment group(observation group,n=40).After continuous treatment for 8 weeks,the treatment effect was evaluated by Bech-Rafaelsdn Mania Rating Scale(BRMS).The serum levels of BDNF,GDNF,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and interleukin-10(IL-10)were measured by enzyme-linked immunosorbent assay(ELISA).Results:After 8 weeks of treatment,the BRMS score of the observation group was significantly lower than that of the control group(P<0.05),but their clinical total effective rate was obviously higher than that of the control group(95.00%vs.80.00%,P<0.05).The serum levels of BDNF and GDNF in the observation group after 8 weeks of treatment were notably higher than those in the control group(P<0.05),while the levels of TNF-αand IL-1βin the observation group were lower than those in the control group(P<0.05).There was no significant difference in the serum IL-10 levels,the incidence and total incidence of somnolence,constipation,dizziness,taste and anorexia between the two groups after treatment(P>0.05).Conclusion:Quetiapine combined with magnesium valproate sustained-release tablets effectively improve the therapeutic effect of bipolar disorder manic episode patients,improve the serum levels of BDNF,GDNF and inflammatory factors,and do not increase the risk of adverse reactions.
作者
斯亮
王燕燕
卢远波
SI Liang;WANG Yan-yan;LU Yuan-bo(Department of Psychiatry,1.Wuhan Mental Health Center,Wuhan 430014,Hubei;Xuancheng Fourth People's Hospital,Xuancheng 242000,Anhui,China)
出处
《川北医学院学报》
CAS
2021年第10期1383-1386,共4页
Journal of North Sichuan Medical College
关键词
双相情感障碍
躁狂
喹硫平
丙戊酸镁缓释片
脑源性神经营养因子
胶质细胞源性神经营养因子
炎性因子
Bipolar disorder
Mania
Quetiapine
Magnesium valproate sustained release tablets
Brain-derived neurotrophic factor
Glial cell-derived neurotrophic factor
Inflammatory factor
