摘要
目的探讨血浆内皮素(PET-1)、一氧化氮(NO)及醛固酮(ALD)在肾性高血压中的表达及与肾功能、血压的相关性。方法选取2018年10月至2020年10月本院收治的60例肾性高血压患者作为观察组,选取同期在本院体检的48例原发性高血压患者设为原发性高血压组,另选取同期在本院进行健康体检的48例无高血压的健康人群设为对照组。比较三组PET-1、NO、ALD水平,分析水平PET-1、NO、ALD水平与肾功能指标、血压的相关性,绘制ROC曲线,分析PET-1、NO、ALD单独检测及三者联合检测对发生肾性高血压的预测价值。结果3组PET-1、NO及ALD水平:观察组>原发性高血压组>对照组,差异均有统计学意义(P<0.05)。PET-1、NO及ALD水平与肾性高血压患者肾功能相关指标(BUN、Cr、Cystatin C、BMG、UA)呈正相关(P<0.05),与肾性高血压患者血压呈正相关(P<0.05)。PET-1、NO、ALD水平及三者联合曲线下面积分别为0.854、0.843、0.860、0.993,各指标曲线下面积以联合检测最大。结论PET-1、NO及ALD与肾性高血压患者肾功能、血压相关,临床工作中可通过对高血压人群加强联合PET-1、NO及ALD检测,以提高早期肾性高血压的诊断率。
Objective To study the expression of endothelin(PET-1),nitric oxide(NO)and aldosterone(ALD)in patients with renal hypertension and their correlation with renal function and blood pressure.Methods A total of 60 patients with renal hypertension admitted to this hospital from October 2018 to October 2020 were selected as the observation group,48 patients with essential hypertension who had physical examination in this hospital during the same period were selected as the essential hypertension group,and 48 healthy people without hypertension were selected as the control group.The levels of PET-1,NO and ALD in the three groups were compared,the correlations between the levels of PET-1,NO and ALD,renal function index and blood pressure were analyzed.The ROC curve was drawn to analyze the predictive value of PET-1,NO and ALD as well as the combined detection of the three in the occurrence of renal hypertension.Results The levels of PET-1,NO and ALD in the three groups were as follows:the observation group>the essential hypertension group>the control group,the difference was statistically significant(P<0.05).The levels of PET-1,NO and ALD were positively correlated with renal function indexes(BUN,Cr,Cystatin C,BMG,UA)in patients with renal hypertension(P<0.05).The levels of PET-1,NO and ALD were positively correlated withthe blood pressure of patients with renal hypertension(P<0.05).The areas under the curves of PET-1,NO,ALD and the combined curve of the three were 0.854,0.843,0.860,0.993,respectively.The area under the combined detection curve was the largest.Conclusion PET-1,NO and ALD are related to renal function and blood pressure in patients with renal hypertension.Clinically,the combined PET-1,NO and ALD detection can be strengthened in hypertensive populations to improve the diagnosis rate of early renal hypertension.
作者
叶扬梅
李玲芝
王韦乐
YE Yangmei;LI Lingzhi;WANG Weile(Department of Nephrology,the Eighth People's Hospital of Hefei,Hefei,Anhui,China,238000;Department of Nephrology,the First People's Hospital of Hefei,Hefei,Anhui,China,230001)
出处
《分子诊断与治疗杂志》
2021年第10期1709-1712,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省自然科学基金(16808085MH216)。
