摘要
虎杖苷是从传统中药虎杖中分离出的一种多酚类单体化合物,是虎杖的主要有效成分,具有多种药理活性。近年来,有关虎杖苷药理作用及机制的研究日益增多。现代药理学研究表明,虎杖苷对神经系统,心脑血管系统,呼吸系统等均有保护作用,对肝、肾、肺等器官亦作用明显,其调节血糖血脂的作用对抗动脉粥样硬化效果显著;其抗纤维化的作用对肝、肾保护效果明显。虎杖苷对多种肿瘤细胞均有抑制作用,可抑制肿瘤细胞增殖并诱导肿瘤细胞凋亡。虎杖苷还具有抗炎,保护骨髓,促进创面愈合,抗辐射等药理活性。笔者查阅有关虎杖苷的药理作用文献发现其单个药理作用机制往往受多靶点蛋白、多条通路调控,但大多还未明确其作用靶点,有待深入研究。该文就近5年来有关虎杖苷的药理作用及机制研究进展进行归纳总结,并对其研究现状及未来研究方向提出相关建议,以期拓宽科研者的研究思路,加快明确其发挥药效作用的靶点,为虎杖苷的进一步开发利用提供科学的理论依据。
Polydatin,a polyphenolic compound,is the main active component of Chinese medicine Polygoni Cuspidati Rhizoma et Radix and has a variety of pharmacological activities. In recent years,there are more studies on the pharmacological effects and mechanisms of polydatin. Modern pharmacological studies show that polydatin has protective effects on the nervous system,cardio-cerebral vascular system,and respiratory system,and also has significant effects on the liver,kidney,lung,and other organs. Its effect of regulating blood glucose and blood lipid on atherosclerosis is significant,and the anti-fibrosis effect is significant on the liver and kidney. Polydatin can inhibit many types of tumor cells,suppress proliferation and induce apoptosis of tumor cells. Polydatin can also resist inflammation and radiation,protect bone marrow,and promote wound healing. Based on the literature on the pharmacological effects of polydatin,the authors found that the single pharmacological mechanism of polydatin is often regulated by multi-target proteins and multiple pathways,but the most of action targets are unclear,which needs to be further investigated. This study summarized the research progress on the pharmacological action and mechanism of polydatin in the past five years and put forward some suggestions on its present research situation and future research direction to broaden the research ideas of researchers and speed up the identification of the targets of its pharmacological effect. This study is expected to provide a scientific theoretical basis for the further development and utilization of polydatin.
作者
林思
秦慧真
邓玲玉
张淼
谢凤凤
朱华
LIN Si;QIN Hui-zhen;DENG Ling-yu;ZHANG Miao;XIE Feng-feng;ZHU Hua(Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第22期241-250,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西壮瑶药重点实验室项目(桂科基字[2014]32号)
广西壮瑶药协同创新中心项目(桂教科研[2013]20号)
广西第八批特聘专家项目(壮瑶药质量标准研究,桂人才通字[2019]13号)
广西一流学科中药学(民族药学)(桂教科研[2018]12号)。
关键词
虎杖苷
药理作用
作用靶点
机制
研究进展
polydatin
pharmacological effect
action target
mechanism
research progress
