摘要
目的探讨早期子宫颈癌患者贫血与临床病理特征的关系及其对预后的影响。方法选取2011年3月至2016年3月南京医科大学附属明基医院、南京鼓楼医院、南京梅山医院诊治的421例行根治性手术治疗及盆腔淋巴结清扫术的子宫颈癌患者作为研究对象。根据术前血红蛋白治疗浓度将其分为贫血组(n=92)和非贫血组(n=329)。比较两组的临床病理资料,对影响盆腔淋巴结转移(PLNM)的因素进行Logistic回归模型分析,并利用受试者工作特征(ROC)曲线对模型进行评价,利用Bootstrap重复取样的方法对模型进行内部验证;通过Cox比例风险回归对可能影响患者复发转移的因素进行分析。结果国际妇产科联盟(FIGO)分期、非鳞癌、肿瘤直径>4cm、分化程度>1级、淋巴血管间隙侵犯(LVSI)、贫血、宫旁浸润是影响PLNM发生的独立危险因素(P<0.05);纳入贫血的模型可以更好地预测PLNM;FIGO分期、病理类型、PLNM、贫血是影响早期子宫颈癌患者预后的关键风险因素(P<0.05)。结论贫血不仅会促进早期子宫颈癌患者PLNM,也会直接影响患者预后。
Objective To explore the relationship between anemia and clinicopathological features and its effect prognosis in patients with early cervical cancer.Methods A total of 421 cases with cervical cancer who un-derwent radical operation and pelvic lymph node dissection in the Affiliated BenQ Hospital of Nanjing Medical Uni-versity,Nanjing Drum Tower Hospital and Nanjing Meishan Hospital from March 2011 to March 2016 were divided into anemia group and non-anemia group according to the preoperative hemoglobin concentration.The clinicopatho-logical data of the two groups were compared,using Logistic regression model to analyze the factors affecting pelvic lymph node metastasis(PLNM),and the model was evaluated by ROC.The model was verified by Bootstrap repeat-ed sampling,and the factors that may affect the recurrence and metastasis of patients were analyzed by Cox propor-tional hazard regression.Results FIGO stage,non-squamous cell carcinoma,tumor diameter>4 cm,degree of differentiation>grade 1,LVSI,anemia,para-uterine invasion were independent risk factors for PLNM.The inclu-sion of anemia model can better predict PLNM.FIGO stage,pathological type,PLNM and anemia are the key risk factors affecting the prognosis of patients with early cervical cancer.Conclusions Anemia not only can promote PLNM in patients with early cervical cancer,but also directly affect the prognosis of patients.
作者
严雪梅
单伟斌
杨小明
洪颖
佘燕
杨巍巍
陈珂
黎明
王诗韵
YAN Xuemei;SHAN Weibin;YANG Xiaoming;HONG Ying;SHE Yan;YANG Weiwei;CHEN Ke;LI Ming;WANG Shiyun(Department of Obstetrics and Gynecology,the Affiliated BenQ Hospital of Nanjing Medical University,Nanjing 210019,Jiangsu,China;Department of Gynecology,Nanjing Drum Tower Hospital,Nanjing 210008,Jiangsu,China;Department of Obstetrics and Gynecology,Nanjing Meishan Hospital,Nanjing 210039,Jiangsu,China)
出处
《中国性科学》
2021年第10期88-91,共4页
Chinese Journal of Human Sexuality
关键词
早期子宫颈癌
贫血
盆腔淋巴结转移
预后
关系
Early cervical cancer
Anemia
Pelvic lymph node metastasis
Prognosis
Relationship
