摘要
目的考察氟尿嘧啶注射液与临床常用的地塞米松磷酸钠注射液、注射用泮托拉唑钠等5种药物配伍的稳定性,为临床合理用药提供依据。方法将氟尿嘧啶分别与地塞米松磷酸钠注射液、注射用泮托拉唑钠等5种临床用注射液配伍,分别于0、0.5、1、2、4、6 h考察配伍后混合液的外观、pH值、渗透压、紫外吸光度值A和不溶性微粒的变化情况。结果地塞米松磷酸钠注射液、盐酸阿扎司琼注射液、盐酸格拉司琼注射液和盐酸甲氧氯普胺注射液与氟尿嘧啶注射液配伍后6 h内混合液的外观、pH值、渗透压和紫外吸光度值A均符合规定,注射用泮托拉唑钠与氟尿嘧啶注射液配伍后的混合液在2 h内外观、pH值、渗透压和紫外吸光度值A符合规定。5种混合液的不溶性微粒数均呈下降趋势,于6 h时符合规定。结论氟尿嘧啶注射液可与地塞米松磷酸钠注射液、注射用泮托拉唑钠等5种药物配伍使用,其中注射用泮托拉唑钠应在2 h内输注完毕。
Objective To investigate the compatible stability of Fluorouracil Injections with Dexamethasone Sodium Phosphate Injections,Pantoprazole Sodium for Injection etc,so as to provide evidence for clinical rational drug use.Methods Fluorouracil Injections were compatible with Dexamethasone Sodium Phosphate Injections and Pantoprazole Sodium for Injection etc.The appearance,pH value,osmotic pressure,ultraviolet absorbance(UV)value A and insoluble particles of the mixtures were investigated after compatibility at 0,0.5,1,2,4 and 6 hours respectively.Results All of the mixtures were stable within 6 hours in terms of the appearance of the mixture,pH value,osmotic pressure and UV value A,except for the mixture compatible with Pantoprazole Sodium for Injection,which was stable within 2 hours.The number of insoluble particles in the 5 mixtures showed a decreasing trend,which was in accordance with the regulations within 6 hours.Conclusion Fluorouracil Injections can be used with Dexamethasone Sodium Phosphate Injections and Pantoprazole Sodium for Injection etc.among which the infusion mixture of Pantoprazole Sodium for Injection should be used up within 2 hours.
作者
朱辉娅
谢永忠
凌志刚
姚玲
方先骏
ZHU Huiya;XIE Yongzhong;LING Zhigang;YAO Ling;FANG Xianjun(Department of Pharmacy,Huangshan City People′s Hospital,Huangshan 245000,China;Department of Pharmacy,Huangshan Product Quality Inspection Institute,Huangshan 245000,China;Department of Pharmacy,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)
出处
《西北药学杂志》
CAS
2021年第5期775-778,共4页
Northwest Pharmaceutical Journal
基金
安徽省自然科学基金项目(编号:1908085QH352)。
关键词
氟尿嘧啶注射液
配伍
稳定性
Fluorouracil Injection
compatible
stability
