摘要
目的观察对药女贞子-续断对卵巢早衰模型大鼠相关激素水平影响。方法将60只大鼠随机抽取10只设为空白对照组,其余大鼠采用灌服雷公藤多苷的方法建立模型。将造模成功大鼠随机分为空白模型组、西药对照组、中药高剂量组、中药中剂量组、中药低剂量组,每组8只大鼠。观察各组实验大鼠药物干预后卵巢指数、子宫指数观测、脑垂体卵泡刺激素(FSH)、黄体生成素(LH)和血清雌二醇(E2)、孕酮(P)、FSH、LH水平变化情况。结果对药"女贞子-续断"高、中、低三种剂量均能够提高模型大鼠的卵巢指数和子宫指数(P<0.05,P<0.01),提升血清E2、P水平(P<0.05,P<0.001),降低脑垂体和血清FSH、LH水平(P<0.05)。药物干预作用与用药剂量具有明显的正相关性。结论对药"女贞子-续断"具有类雌激素活性,能够有效调节体内激素水平,防治卵巢早衰。最佳的用药剂量有待进一步研究。
Objective Observe the effects of a pair of herbs of "Ligustrum lucidum-Dipsacus" on the levels of related hormones in rats with premature ovarian failure. Methods Ten rats were randomly selected as blank control group from 60 rats.The other rats were treated with Tripterygium wilfordii polyglycoside to establish the model.The successful model rats were randomly divided into blank model group, western medicine control group, high-dose group, medium dose group and low-dose group, there were 8 rats in each group.The changes of ovarian index, uterine index, pituitary follicle stimulating hormone(FSH), luteinizing hormone(LH) and serum estradiol(E;), progesterone(P), FSH, LH levels in each group were observed.Results High, medium and low doses of "Ligustrum lucidum-Dipsacus" could increase the ovarian index and uterine index(P<0.05,P<0.01),increase the serum E;and P levels(P<0.05,P<0.001), and reduce the levels of pituitary gland and serum FSH and LH(P<0.05).There was a significant positive correlation between drug intervention and dosage. Conclusion "Ligustrum lucidum-Dipsacus" has estrogen like activity, which can effectively regulate hormone levels in vivo and prevent premature ovarian failure.The optimal dosage needs further study.
作者
尚坤
周彤
张欣
SHANG Kun;ZHOU Tong;ZHANG Xin(Changchun University of Chinese Medicine,Changchun Jilin 130117 China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2021年第7期1585-1587,共3页
Lishizhen Medicine and Materia Medica Research
基金
吉林省中医药科技项目(2019054)
吉林省大学生创新创业训练计划项目(201810199072)。
关键词
对药
女贞子
续断
卵巢早衰
激素
A pair of herbs
Ligustrum lucidum
Dipsacus
Premature ovarian failure
Hormone
