血清抗Sa抗体、抗环瓜氨酸抗体在类风湿性关节炎患者中的检测意义探讨被引量：1

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摘要目的探讨血清抗Sa(anti-Sa)、抗环瓜氨酸抗体(anti-CCP)在类风湿性关节炎(RA)患者中的检测意义。方法以413例RA患者为研究对象,按照类风湿关节炎患者病情评价(DAS28评分),以DAS28评分≤3.2分为轻度组(n=206),以DAS28评分>3.2分为中重度组(n=207),进行回顾性分析,比较两组患者血清anti-Sa、anti-CCP水平,采用Pearson相关性分析anti-Sa、anti-CCP与DAS28评分的相关性,采用受试者工作特征(ROC)曲线,评估anti-Sa、anti-CCP及联合诊断RA患者病情严重程度的诊断价值。结果中重度组患者anti-Sa、anti-CCP水平均明显高于轻度组(P<0.05);anti-Sa、anti-CCP与DAS28评分呈正相关(P<0.05);anti-Sa、anti-CCP诊断RA患者病情严重程度的ROC曲线的面积(AUC)分别为0.737,0.719,截断值分别为39.91U/mL,20.43U/mL,敏感度分别为51.69%,62.80%,特异度分别为83.50%,70.83%;联合诊断RA的ROC曲线AUC为0.803,敏感度为73.91%,特异度为72.82%,联合评估的AUC明显大于anti-Sa、anti-CCP单独评估(P<0.05)。结论血清anti-Sa、anti-CCP均与RA患者病情严重程度关系密切,二者联合检测评估其病情的效能较单独检测更为理想,临床应用价值较高。

作者操良会

机构地区长寿区中医院检验科

出处《哈尔滨医药》 2021年第4期47-49,共3页 Harbin Medical Journal

关键词血清抗Sa抗体抗环瓜氨酸抗体类风湿性关节炎

分类号 R453 [医药卫生—治疗学]

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