摘要
目的观察九味益脑颗粒联合奥拉西坦治疗血管性痴呆的临床疗效及对血清脑红蛋白(NGB)的影响。方法将我院收治的88例血管性痴呆患者随机分为对照组与联合组各44例。对照组患者给予奥拉西坦治疗联合组患者给予九味益脑颗粒联合奥拉西坦治疗治疗。比较两组患者临床疗效、不良反应及治疗前后认知功能(MMSE量表)、日常生活能力(ADL量表)、血清相关指标血清超氧化物歧化酶(SOD)、脑源性神经营养因子(BDNF)、脑红蛋白(NGB)水平和颅内动脉血流动力学指标血管收缩峰(Vs)、舒张峰流速(Vm)、颅内动脉搏动指数(PI)。结果治疗后,联合组患者临床治疗总有效率明显优于对照组(P<0.05);两组患者MMSE、ADL评分均明显升高,且联合组评分高于对照组(P<0.05);两组血清SOD、BDNF、NGB水平均明显升高,且联合组水平均高于对照组(P<0.05);两组患者Vs、Vm均明显升高、PI明显降低且联合组上述各指标均优于对照组(P<0.05);两组不良反应总发生率比较无明显差异(P>0.05)。结论应用九味益脑颗粒联合奥拉西坦治疗血管性痴呆患者临床疗效较好,不但可改善患者认知功能与日常生活能力,减轻患者氧化应激反应,而且能保护神经元,同时安全性较高,值得临床应用。
Objective To observe the clinical efficacy of Jiuwei Yinao Granules combined with oxiracetam in treatment of vascular dementia and its effect on serum neuroglobin.Methods A total of 88 patients with vascular dementia were randomly divided into control group and combination group with cases 44 each.Control group was treated with oxiracetam,combination group was treated with Jiuwei Yinao Granules combined with oxiracetam.The clinical efficacy,adverse reactions cognitive function(MMSE scale) Activities of daily living(ADL) scale,serum related indexes(SOD,BDNF,NGB) and intracranial arterial hemodynamics(Vs,Vm,PI) before and after treatment were compared between the two groups.Results After treatment,the total effective rate of combination group was significantly higher than that of control group(P<0.05);the MMSE and ADL scores of both groups were significantly increased,and combination group were higher than control group(P<0.05);the serum SOD,BDNF and Ngb levels of both groups were significantly increased,and observation group were higher than control group(P<0.05);the Vs and Vm of both groups significantly increased,and combination group were higher than control group(P<0.05);there was no significant difference in the rate of adverse reactions between the two groups(P>0.05).Conclusion Jiuwei Yinao Granules combined with oxiracetam has good clinical efficacy in treatment of vascular dementia,which can increase cognitive function and daily living ability,reduce the oxidative stress reaction of patients,and protect the neurons with high safety.It is worthy of clinical application.
作者
徐雪怡
黎顺成
杨进
梁潇
XU Xueyi;LI Shuncheng;YANG Jin;LIANG Xiao(Anning Hospital of Hainan Province,Haikou 570206;Guangxi University of Chinese Medicine,Nanning 530001)
出处
《湖北中医药大学学报》
2021年第5期65-67,共3页
Journal of Hubei University of Chinese Medicine
基金
广西自然科学基金项目(项目编号:2018JJB140222)。
