摘要
目的:探讨清胰汤联合奥美拉唑及奥曲肽治疗急性胰腺炎(acute pancreatitis,AP)的效果及对血钙、C反应蛋白(CRP)的影响。方法:选择2018年6月至2021年3月在安徽省太和县人民医院就诊的AP患者84例,采用随机数字表法分为观察组和对照组,每组42例。对照组患者采用常规西药奥美拉唑联合奥曲肽治疗,观察组患者在对照组治疗的基础上加用清胰汤。比较两组患者治疗后的临床疗效,比较两组患者治疗前和治疗3 d后血钙、CRP、白细胞计数(WBC)水平及腹痛数字评定量表(numerical rating scale,NRS)评分,记录患者症状恢复时间(腹胀缓解时间、住院时间和禁食时间),比较两组患者胃肠功能恢复情况(肠鸣音恢复时间、排气恢复时间和排便恢复时间),观察治疗期间两组患者并发症发生情况。结果:治疗后,观察组患者的总有效率为92.86%(39/42),明显高于对照组的76.19%(32/42),差异有统计学意义(P<0.05)。治疗3 d后,两组患者的CRP、WBC水平明显低于治疗前,且观察组患者明显低于对照组;两组患者的血钙水平明显高于治疗前,且观察组患者明显高于对照组,上述差异均有统计学意义(P<0.05)。治疗后,观察组患者腹胀缓解时间、住院时间和禁食时间明显短于对照组,腹痛NRS评分明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者肠鸣音恢复时间、排气恢复时间和排便恢复时间明显短于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患者的并发症发生率为9.52%(4/42),明显低于对照组的26.19%(11/42),差异有统计学意义(P<0.05)。结论:采用清胰汤联合奥美拉唑及奥曲肽治疗AP患者的效果较好,能有效降低CRP、WBC水平,改善血钙水平,缩短临床症状恢复时间,改善胃肠功能,减少并发症的发生。
OBJECTIVE:To explore the efficacy of Qingyi decoction combined with omeprazole and octreotide in the treatment of acute pancreatitis(AP)and its effects on serum calcium and C-reactive protein(CRP).METHODS:Totally 84 patients with AP admitted into Anhui Taihe County People’s Hospital from Jun.2018 to Mar.2021 were extracted to be divided into the observation group and the control group via the random number table,with 42 cases in each group.The control group was treated with omeprazole combined with octreotide,while the observation group received Qingyi decoction based on the control group.The clinical efficacy after treatment,levels of serum calcium,CRP and white blood cell count(WBC)and abdominal pain numeric rating scale(NRS)score before treatment and 3 d after treatment in two groups were compared.The recovery time of symptoms(relief time of abdominal distension,length of stay,fasting time)was recorded.The recovery conditions of gastrointestinal function(recovery time of bowel sound,exhaust and defecation)were compared between two groups.The occurrence of complications in both groups during treatment was observed.RESULTS:After treatment,the total effective rate of the observation group was 92.86%(39/42),significantly higher than 76.19%(32/42)of the control group,the difference was statistically significant(P<0.05).After treatment of 3 d,the levels of CRP and WBC in two groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group;the blood calcium levels of two groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group,with statistically significant differences(P<0.05).After treatment,the relief time of abdominal distension,length of stay and fasting time in the observation group were significantly shorter than those in the control group,the NRS score was lower than the control group,with statistically significant differences(P<0.05).After treatment,the recovery time of bowel sound,exhaust and defecation in the observation group were significantly shorter than those in the control group,with statistically significant differences(P<0.05).During treatment,the incidence of complications in the observation group was 9.52%(4/42),significantly lower than 26.19%(11/42)in the control group,the difference was statistically significant(P<0.05).CONCLUSIONS:The efficacy of Qingyi decoction combined with omeprazole and octreotide in the treatment of AP is remarkable,which can effectively reduce the levels of CRP and WBC,improve the level of serum calcium,shorten the recovery time of clinical symptoms,improve the gastrointestinal function and reduce the incidence of complications.
作者
赵蕊
王亚雷
郭庆涛
李明明
ZHAO Rui;WANG Yalei;GUO Qingtao;LI Mingming(Dept.of Digestive System,Anhui Taihe County People’s Hospital,Anhui Taihe 236600,China;Dept.of Digestive System,the First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230031,China)
出处
《中国医院用药评价与分析》
2021年第10期1165-1168,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家重点研发计划项目(No.2016YFC1302802-09)。
关键词
清胰汤
奥美拉唑
奥曲肽
急性胰腺炎
疗效
C反应蛋白
血钙
Qingyi decoction
Omeprazole
Octreotide
Acute pancreatitis
Efficacy
C-reactive protein
Serum calcium
