摘要
Cathepsin L(CTSL),a member of the cysteine protease cathepsin family,is an important Lysosomal peptidase,which has the best activity in an acidic environment and less activity in a neutral environment.Its physiological function involves proteolysis,antigen presentation,T cell development,cell apoptosis,and embryonic development,and is closely related to the occurrence and development of various types of cancer,cardiovascular disease,and kidney disease.In this paper,the role and mechanism of CTSL in the development of atherosclerosis,coronary heart disease,restenosis,abdominal aortic aneurysm,and dilated cardiomyopathy were briefly reviewed.
基金
supported by the National Natural Science Foundation of China(No.81870279)。
