摘要
心脏外科手术术中心肌缺血再灌注(ischemia and reperfusion,I/R)导致线粒体损伤,继而引起心肌细胞能量代谢改变、稳态破坏、活性氧产生和DNA损伤,激活心肌细胞凋亡和坏死信号,最终导致心肌功能障碍或心力衰竭。与以往I/R治疗靶点集中于某条通路或某个介质不同,自体线粒体移植(autologous mitochondria transplantation,AMT)将自身健康部位或器官组织的有呼吸活性的线粒体移植到I/R组织中,替代或修复已受损的线粒体,帮助组织和细胞功能恢复。近年来AMT在心肌I/R防治中取得了显著效果,本文就AMT在I/R心肌保护中的作用及机制进行综述。
In cardiac surgery such as myocardial infarction,congenital heart disease,and heart transplantation,myocardial ischemia-reperfusion(I/R)damages mitochondria,which in turn causes myocardium energy metabolism disturbance,homeostatic destruction,reactive oxygen species production and DNA damage,and activates myocardium apoptosis and necrosis signals,which eventually lead to myocardial dysfunction or heart failure.Different from the previous I/R treatment targets focusing on a certain pathway or a certain medium,autologous mitochondrial transplantation(AMT)is an emerging method,which transplant viable and respiration-competent mitochondria from healthy organs or tissues to the injured sites which suffer from I/R injury,to replace or repair damaged mitochondria.In recent years,AMT has achieved remarkable results in the prevention and treatment of myocardial I/R.This article reviews the role and mechanism of AMT in I/R myocardial protection.
作者
李聪
潘燕军
祝忠群
Li Cong;Pan Yanjun;Zhu Zhongqun(Department of Cardiothoracic Surgery,Shanghai Children's Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China)
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2021年第10期631-634,共4页
Chinese Journal of Thoracic and Cardiovascular Surgery
