摘要
目的探讨醋酸戈舍瑞林缓释植入剂(GAS-RD)联合孕三烯酮在子宫内膜异位症(EMT)手术患者中的应用。方法选择2019年8月至2020年8月洛阳新区人民医院收治的80例EMT患者作为研究对象,根据随机数表法分为对照组和观察组,各40例。患者均接受腹腔镜手术治疗,对照组术后接受孕三烯酮治疗,观察组接受GAS-RD联合孕三烯酮治疗。比较两组患者治疗6个月时临床疗效;治疗前、治疗6个月时,比较两组血管内皮生长因子(VEGF)、糖类抗原125(CA125)、基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)及治疗期间不良反应情况。结果治疗6个月,观察组总有效率[97.50%(39/40)]高于对照组[80.00%(32/40)](P<0.05);治疗6个月后,两组血清VEGF、CA125水平均低于治疗前,且观察组低于对照组(P<0.05);治疗6个月,两组血清MMP-9、TNF-α水平低于治疗前,且观察组低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 GAS-RD联合孕三烯酮可有效减轻EMT手术患者炎症水平,降低子宫内膜损伤,提高临床疗效。
Objective To investigate the application of goserelin acetate sustained-release implant(GAS-RD) combined with gestrinone in patient with endometriosis(EMT).Methods Eighty patients with EMT treated in New Area People’s Hospital of Luoyang from August 2019 to August 2020 were selected as the research subjects,according to a random number table method,they were divided into control group and observation group,with 40 cases in each group.All patients underwent laparoscopic surgery,the control group was treated with gestrinone,and the observation group was treated with GAS-RD combined with gestrinone.The clinical efficacy of the two groups were compared after 6 months of treatment.Before and 6 months after treatment,vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α) and adverse reactions during treatment of the two groups were compared.Results After 6 months of treatment,the total effective rate in the observation group [97.50%(39/40)] was higher than that in the control group [80.00%(32/40)](P<0.05).After 6 months of treatment,the levels of serum VEGF and CA125 in both groups were lower than those before treatment,and the observation group was lower compared with the control group(P<0.05).After 6 months of treatment,the levels of serum MMP-9 and TNF-α in both groups were lower than those before treatment,and the observation group was lower when compared with the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion GAS-RD combined with gestrinone can effectively reduce the level of inflammation,reduce endometrial injury and improve the clinical efficacy in patients with EMT.
作者
牛利娜
NIU Lina(Department of Obstetrics and Gynecology,New Area People’s Hospital of Luoyang,Luoyang 471000,China)
出处
《河南医学研究》
CAS
2021年第32期6078-6080,共3页
Henan Medical Research
