摘要
目的探究老年缺血性脑卒中患者采用阿托伐他汀治疗对其氧化应激与脂质过氧化水平的影响。方法于2017年4月至2019年7月,随机选取本院神神经内科收治的82例老年缺血性脑卒中患者作为此次研究对象,并按照数字表法分为两组,对比组41例患者采用常规治疗,试验组41例患者在常规治疗下加用阿托伐他汀治疗,并对两组患者NIHSS评分、日常生活活动能力评分、8-异前列腺素与氧化低密度脂蛋白水平进行对比。结果试验组患者NIHSS评分明显比对比组的低,日常生活活动能力评分明显比对比组高(P<0.05);对比组患者治疗后8-异前列腺素与氧化低密度脂蛋白水平均高于治疗前(P<0.05);而试验组患者治疗后8-异前列腺素与氧化低密度脂蛋白水平较治疗前比较差异不明显(P>0.05),但较对比组更低(P<0.05)。结论老年缺血性脑卒中患者采用阿托伐他汀治疗的临床效果显著,可有效控制氧化应激与脂质过氧化水平,加快神经功能的恢复,提高日常生活活动能力。
Objective To investigate the effects of atorvastatin on oxidative stress and lipid peroxidation in elderly patients with ischemic stroke.Methods During the period from April 2017 to July 2019,82 elderly patients with ischemic stroke were randomly selected as the subjects of this study by the department of neurology,and were divided into two groups according to the digital scale method.In contrast,41 patients in the compareative group used conventional treatment.The 41 patients in the experimental group were treated with atorvastatin under routine treatment,and the NIHSS score,daily activity ability score,8-isoprostaglandin and oxidized low-density lipoprotein levels were compared between the two groups.Results The NIHSS score was significantly lower in the experimental group than in the comparative group(P<0.05);patients in the experimental group scored significantly higher than the comparative group(P<0.05);after treatment,8-isoprostaglandin and oxidized low-density lipoprotein water were on average higher than before treatment(P<0.05);the levels of 8-isoprostaglandin and oxidized low-density lipoprotein after treatment in the experimental group were not significantly different from those before treatment(P>0.05),but they were lower than those in the control group(P<0.05).Conclusion The clinical effect of atorvastatin in elderly patients with ischemic stroke is remarkable.It can effectively control the level of oxidative stress and lipid peroxidation,accelerate the recovery of nerve function and improve the ability of daily life activities.
作者
王旭
WANG Xu(Neurology Department Liaoyang Central Hospital,Liaoyang 111000,China)
出处
《中国医药指南》
2021年第31期58-60,共3页
Guide of China Medicine
