摘要
目的分析血液净化对急性心力衰竭合并周身浮肿患者心功能的影响。方法选取2018年1月至2020年9月辽宁省大连市友谊医院的68例急性心力衰竭合并周身浮肿患者为研究对象,根据不同治疗方法分成A组与B组,每组各34例。A组应用常规药物治疗,B组应用常规药物联合血液净化治疗,两组均治疗8周。比较两组临床疗效、心力衰竭标志物(B型利钠肽)、心功能(左室舒张末期内径、左室收缩末期内径、左室射血分数)及血气分析指标(动脉血二氧化碳分压、动脉血氧分压、血氧饱和度)。结果治疗后B组总有效率高于A组(P<0.05);治疗后两组利钠肽水平较治疗前降低,且B组B型利钠肽水平低于A组(P<0.05);治疗后两组左室舒张末期内径、左室收缩末期内径均小于治疗前,左室射血分数高于治疗前(P<0.05);治疗后B组左室舒张末期内径、左室收缩末期内径均低于A组,左室射血分数高于A组(P<0.05);治疗后两组动脉血二氧化碳分压低于治疗前,动脉血氧分压、血氧饱和度均高于治疗前,且B组动脉血二氧化碳分压低于A组,动脉血氧分压、血氧饱和度均高于A组(P<0.05)。结论血液净化治疗急性心衰合并周身浮肿的效果确切,总有效率高,能明显改善患者的心衰标志物、心功能指标与血气分析指标,值得推行。
Objective To analyze the effect of blood purification on cardiac function in patients with acute heart failure and peripheral edema.Methods A total of 68 patients with acute heart failure and peripheral edema in Dalian Friendship Hospital,Liaoning Province from January 2018 to September 2020 were selected,and divided into group A and group B according to different treatment methods,with 34 cases in each group.Group A was treated with conventional drugs,and group B was treated with conventional drugs combined with blood purification.The clinical efficacy,heart failure markers(B-type natriuretic peptide),cardiac function(left ventricular end diastolic diameter,the left ventricular end systolic diameter,left ventricular ejection fraction) and blood gas analysis indicators(arterial partial pressure of carbon dioxide,arterial partial pressure of oxygen,oxygen saturation) of the two groups were compared.Results The total effective rate in group B was higher than that in group A(P < 0.05);after treatment,the level of B-type natriuretic peptide in the two groups was lower than that before treatment,the level of B-type natriuretic peptide in group B after treatment was lower than that in group A(P < 0.05).After treatment,the left ventricular end diastolic diameter and the left ventricular end systolic diameter of the two groups were lower than before treatment,left ventricular ejection fraction was higher than before treatment(P < 0.05),and the left ventricular end diastolic diameter and left ventricular end systolic diameter of group B were lower than those of group A,the left ventricular ejection fraction was higher than that of group A(P < 0.05);after treatment,arterial blood carbon dioxide was lower than before treatment,arterial blood oxygenpartial pressure and oxygen saturation were higher than before treatment,and arterial blood carbon dioxide in group B was lower than that in group A,arterial blood oxygen partial pressure and oxygen saturation werehigher than those in group A(P < 0.05).Conclusion Blood purification is effective in the treatment of acute heart failure and peripheral edema,and the total effective rate is high.It can significantly improve the heart failure markers,cardiac function indexes and blood gas analysis indexes,which is worthy of promotion.
作者
赵春莉
董志扬
曹昌萌
柳颖
刘菲
宁淑蔚
ZHAO Chunli;DONG Zhiyang;CAO Changmeng;LIU Ying;LIU Fei;NING Shuwei(Department One of Critical Care Medicine,Dalian Friendship Hospital,Liaoning Province,Dalian 116001,China;Department of Geriatrics,Dalian Friendship Hospital,Liaoning Province,Dalian 116001,China)
出处
《中国医药导报》
CAS
2021年第29期73-76,85,共5页
China Medical Herald
基金
辽宁省大连市医学科学研究计划项目(1711034)。
关键词
血液净化
心力衰竭
疗效
心功能
Blood purification
Heart failure
Curative effect
Cardiac function
