摘要
In response to emerging infectious diseases,such as the recent pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),it is critical to quickly identify and understand responsible pathogens,risk factors,host immune responses,and pathogenic mechanisms at both the molecular and cellular levels.The recent development of multiomic technologies,including genomics,proteomics,metabolomics,and single-cell transcriptomics,has enabled a fast and panoramic grasp of the pathogen and the disease.Here,we systematically reviewed the major advances in the virology,immunology,and pathogenic mechanisms of SARS-CoV-2 infection that have been achieved via multiomic technologies.Based on well-established cohorts,omics-based methods can greatly enhance the mechanistic understanding of diseases,contributing to the development of new diagnostics,drugs,and vaccines for emerging infectious diseases,such as COVID-19.
基金
This study was supported by the National Science Fund for Distinguished Young Scholars(82025022)
the Central Charity Fund of the Chinese Academy of Medical Science(2020-PT310-009)
Shenzhen Bay Funding(2020B1111340074,2020B1111340075).
