摘要
目的:分析我院靶向抗肿瘤药物药品不良反应(adverse drug reaction,ADR)的发生情况及特点,为临床用药安全提供参考依据。方法:通过中国医院药物警戒系统(China Hospital Pharmacovigilance System,CHPS),主动监测我院2018年1月至2020年12月期间使用靶向抗肿瘤药物致ADR患者的性别、年龄、药品种类、ADR累及系统、转归情况等信息,进行回顾性分析。结果:94例ADR患者中,男性51例(54.44%)、女性43例(45.56%);平均年龄(62.15±12.17)岁,其中以60~69岁年龄组占比最高,28例(29.79%);不同性别ADR患者的年龄构成之间差异无统计学意义(χ^(2)=2.837,P=0.829)。涉及靶向抗肿瘤药物9种,给药途径主要包括口服42例(44.68%)和静脉滴注52例(55.32%),药物剂型包括片剂42例(44.68%)、注射剂29例(30.85%)、粉针剂23例(24.47%),其中吉非替尼所致ADR最多38例(40.43%)、其次为利妥昔单抗注射液22例(23.40%)和硼替佐米18例(19.15%)。靶向抗肿瘤药物致ADR可同时累及多个器官/系统,其中以消化系统损害最为常见32例(23.70%)、其次为皮肤及其附件21例(15.56%)、全身性损害17例(12.59%)。结论:我院靶向抗肿瘤药物所致ADR以男性和60~69岁老年人群居多,不同种类靶向抗肿瘤药物所致ADR的发生率以及所累及的主要系统或器官存在差异,医护及临床药师应当密切关注用药过程中可能发生的ADR,努力提高临床用药安全性。
Objective:To analyze the occurrence and characteristics of adverse drug reactions(ADR)of targeted anti-tumor drugs,so as to provide evidence for safe clinical medication.Methods:We actively monitored information such as gender,age,drug types,ADR-involved organs/systems,and outcomes of patients with ADR induced by targeted anti-tumor drugs in our hospital from January 2018 to December 2020 through the China Hospital Pharmacovigilance System(CHPS).Results:Among the 94 ADR patients,51(54.44%)were male,and 43(45.56%)were female,with the average age of(62.15±12.17)year;the 60-69 age group accounted for the highest proportion[29.79%(28 cases)];there was no significant difference in the age distribution of ADR patients between different genders(χ^(2)=2.837,P=0.829).9 kinds of targeted anti-tumor drugs were involved.The routes of administr-ation mainly included oral administration(tablets)in 42 cases(44.68%)and intravenous drip in 52 cases(55.32%)[liquid in 29 cases(30.85%)and powder in 23 cases(24.47%)].Of the 94 ADR cases,38 cases(40.43%)were caused by gefitinib,followed by rituximab in 22 cases(23.40%)and bortezomib in 18 cases(19.15%).ADR caused by targeted anti-tumor drugs could involve multiple organs/systems at the same time.Among them,digestive damage[32 cases(23.70%)]was the most common,followed by skin and its appendages[21 cases(15.56%)],and systemic damage[17 cases(12.59%)].Conclusion:ADR caused by targeted anti-tumor drugs in our hospital mainly occur in males and and the the 60-69 age group.The incidences and involved organs/systems vary as types of targeted anti-tumor drugs differ.Doctors,nurses and clinical pharmacists should pay close attention to the ADR that may occur in the course of medication,and strive to improve the safety of clinical medication.
作者
姜尧
夏银川
杨俊
彭霞
杨建
Jiang Yao;Xia Yinchuan;Yang Jun;Peng Xia;Yang Jian(Department of Pharmacy,Bazhong Central Hospital,Bazhong 636000,Sichuan,China;Department of Oncology,Bazhong Central Hospital,Bazhong 636000,Sichuan,China)
出处
《肿瘤预防与治疗》
2021年第10期962-966,共5页
Journal of Cancer Control And Treatment
