摘要
目的使用Er:YAG激光对原发性舍格伦综合征(primary Sj?gren Syndrome,pSS)患者进行治疗,探究该治疗方法的临床疗效。方法纳入2019年1—12月在徐州医科大学附属淮安医院被诊断为pSS患者。将符合纳入标准的79例患者随机分为两组,治疗组39例,对照组40例,治疗组患者使用Er:YAG激光照射腮腺区,对照组不照射激光。每周2次,共进行4周,第5周复诊时对两组患者进行临床检查和问卷调查。结果共有74例患者完成试验,第5周复诊时,治疗组患者唾液分泌量高于对照组(P<0.05)。治疗组患者的黏膜症状愈合率高于对照组(P<0.05)。主观症状方面,治疗组患者Ⅺ、VAS低于对照组患者,GOHAI高于对照组(P均<0.05)。结论使用Er:YAG激光能够增加pSS患者的唾液分泌,并能够有效地改善患者的口腔症状,对于治疗pSS具有良好的临床疗效。
Objective To investigate the clinical efficacy of Er:YAG laser in treatment of primary Sjogren Syndrome(p SS). Methods Patients diagnosed with p SS in Huai’an Hospital Affiliated to Xuzhou Medical University from January to December 2019 were included. 79 patients who met the inclusion criteria were randomly divided into two groups,39 in the treatment group and 40 in the control group. The patients in the treatment group were irradiated with Er:YAG laser twice a week for 4 weeks,and the patients in the control group were not irradiated with laser. Clinical examination and questionnaire survey were conducted for the two groups at the follow-up visit in the fifth week. Results 74 patients finally completed this trial. At the follow-ups,secretion of saliva and healing rate of mucosal symptoms in the treatment group were higher than the control group(P all<0.05). Ⅺ and VAS of patients in the treatment group were lower than the control group while GOHAI of patients in the treatment group were higher than the control group(P all<0.05). Conclusion Er:YAG laser therapy can effectively increase the salivary secretion and improve the oral symptoms of p SS patients. This therapeutic method has a satisfactory clinical efficacy in p SS patients.
作者
汪声明
李芳芳
吴尧
史新连
WANG Shengming;LI Fangfang;WU Yao;SHI Xinlian(Department of Stomatology,the Affiliated Huai'an Hospital of Xuzhou Medical University,Huai'an 223001,China;Department of Ophthalmology,the Affiliated Huai'an Hospital of Xuzhou Medical University,Huai'an 223001,China)
出处
《宁夏医科大学学报》
2021年第9期955-959,共5页
Journal of Ningxia Medical University
