摘要
目的了解重叠乙型肝炎病毒(HBV)或人类免疫缺陷病毒(HIV)感染的丙型肝炎患者基因型流行特点及丙型肝炎病毒(HCV)载量的差异。方法选取2013年1月至2019年12月昆明市第三人民医院收治的丙型肝炎患者3521例作为研究对象,分为HBV/HCV共感染组、HIV/HCV共感染组、单一HCV感染组,收集患者的性别、年龄、民族、感染途径等资料,并进行HCV基因分型和HCV RNA定量检测。结果三组患者在性别、民族、感染途径等方面比较,差异均有统计学意义(P<0.05),HIV/HCV共感染组男性、静脉吸毒所占比例高于单一HCV感染组和HBV/HCV共感染组,而少数民族所占比例高于单一HCV感染组。三组患者共发现4种基因型(1型、2型、3型和6型),12种基因亚型(1a、1b、2a、2b、3a、3b、6a、6e、6k、6n、6v、6ax),均以3型为主,HCV基因型构成比间差异有统计学意义(P<0.05),HIV/HCV共感染组基因3型和未确定型显著高于单一HCV感染者(P<0.05),而基因2型低于HBV/HCV共感染组、单一HCV感染组(P<0.05)。三组感染者HCV RNA滴度差异有统计学意义(P<0.05),HIV/HCV共感染组HCV RNA滴度明显高于HBV/HCV共感染组和单一HCV组(P<0.05)。结论云南地区HCV合并HIV或HBV感染基因型分布呈多样性,在基因型分布和病毒载量上存在差异,HIV/HCV共感染者基因3型和未确定型较单一HCV感染多见,而HBV/HCV共感染者和单一HCV感染患者基因2型较HIV/HCV共感染者多见,HIV/HCV共感染者HCV RNA滴度均高于HBV/HCV共感染者和单一HCV感染者。
Objective To understand genotypic prevalence characteristics and hepatitis C virus(HCV)load differences in patients with overlapping hepatitis B virus(HBV)or human immunodeficiency virus(HIV)infection.Methods A total of 3521 hepatitis C patients admitted to the Third People’s Hospital of Kunming from Jan.2013 to Dec.2019 were selected as the research objects,which were divided into HBV/HCV co-infection group,HIV/HCV co-infection group,and single HCV infection group.Data such as gender,age,nationality,infection route and other data of the patients were collected,and HCV genotyping and HCV RNA quantitative detection were conducted.Results There were statistically significant differences among the 3 groups in gender,nationality,and infection route(P<0.05).The proportion of male and intravenous drug use in the HIV/HCV co-infection group was higher than that in single HCV infection group and the HBV/HCV co-infection group,while the proportion of ethnic minorities was higher than that in the single HCV infection group.A total of 4 genotypes(type 1,type 2,type 3 and type 6)and 12 gene subtype(1a,1b,2a,2b,3a,3b,6a,6e,6k,6n,6v,6ax)were found in the 3 groups of patients,all of which were dominated by type 3.The differences in HCV genotype composition ratio were statistically significant(P<0.05).Genotype 3 and undetermined genotype in HIV/HCV co-infection group were significantly higher than that in single HCV infection group(P<0.05),while genotype 2 was lower than that in HBV/HCV co-infection group and single HCV infection group(P<0.05).There was a statistically significant difference in HCV RNA titer among the 3 groups(P<0.05),and the HCV RNA titer of the HIV/HCV co-infection group was significantly higher than that of the HBV/HCV co-infection group and the single HCV group(P<0.05).Conclusion The genotype distribution of HCV infected with HIV or HBV shows diversity in Yunnan,and there are differences in genotype distribution and viral load.Genotype 3 and unknown genotype of HIV/HCV co-infected patients are more common than single HCV infection,genotype 2 is more common in HBV/HCV co-infected patients and single HCV infected patients than HIV/HCV co-infected patients.The HCV RNA titers of HIV/HCV co-infected patients are higher than those of HBV/HCV co-infected patients and single HCV co-infected patients.
作者
陈友惠
王辉
高建鹏
冯程
李俊义
母昌垒
李黎
CHEN Youhui;WANG Hui;GAO Jianpeng;FENG Cheng;LI Junyi;MU Changlei;LI Li(Department of Hepatology and Gastroenterology,the Third People’s Hospital of Kunming,Kunming 650041,China)
出处
《胃肠病学和肝病学杂志》
CAS
2021年第11期1293-1297,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
云南省科技厅科技计划项目(2018FE001[-275])。
关键词
丙型肝炎病毒
重叠感染
基因分布
病毒学特征
Hepatitis C virus
Co-infection
Genotype distribution
Virological characteristics
