摘要
目的:分析甲巯咪唑和丙硫氧嘧啶治疗妊娠合并甲亢的临床效果。方法:纳入本院2019年6月-2020年6月收治的妊娠合并甲亢患者69例,根据不同用药分为甲巯咪唑组(34例,采用甲巯咪唑片口服治疗)、丙硫氧嘧啶组(35例,采用丙硫氧嘧啶口服治疗)。对比两组患者治疗前后的甲状腺功能、临床症状评分;对比两组患者不良妊娠结局发生率和新生儿不良结局发生率;对比两组患者肝功能损伤发生率和肝功能损伤发生时间。结果:两组治疗前甲状腺功能、临床症状评分比较,差异均无统计学意义(P>0.05)。和甲巯咪唑组比较,丙硫氧嘧啶组患者治疗后游离甲状腺素(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))水平、各项临床症状评分明显较低(P<0.05),治疗后两组促甲状腺激素(TSH)水平比较差异无统计学意义(P>0.05);和甲巯咪唑组比较,丙硫氧嘧啶组患者不良妊娠结局发生率、肝功能损伤发生率明显较高,新生儿不良结局发生率明显较低,肝功能损伤发生时间明显较晚(P<0.05)。结论:丙硫氧嘧啶和甲巯咪唑均可有效治疗妊娠合并甲亢,但两种药物均会产生各自不良反应,应根据患者不同病情合理择药,治疗期间密切监测生命体征,发现异常及时应对。
Objective:To analyze the clinical effect and adverse reactions of Methimazole Tablets and Propylthiouracil in the treatment of pregnancy complicated with hyperthyroidism.Method:Sixty-nine patients with hyperthyroidism who admitted to our hospital from June 2019 to June 2020 were selected and divided into the the Methimazole group(n=34,treated with Methimazole tablets orally)and the Propylthiouracil group(n=35,treated Propylthiouracil Tablets orally)according to different medicines.The thyroid function and clinical symptom scores before and after treatment were compared;the incidence of adverse pregnancy outcomes,the incidence of adverse neonatal outcomes,the incidence of liver damage and the time of occurrence of liver damage were compared between the two groups.Result:There were no significant differences in thyroid function and clinical symptom scores between the two groups before treatment(P>0.05).Compared with the Methimazole group,the free thyroxine(FT_(4)),free triiodothyronine(FT_(3))levels and the scores of various clinical symptoms were significantly lower in the Propylthiouracil group after treatment(P<0.05).There was no statistically significant difference in thyroid-stimulating hormone(TSH)between the two groups(P>0.05).Compared with the Methimazole group,the incidence of adverse pregnancy outcomes and liver function damage were significantly higher in the Propylthiouracil group,while the incidence of adverse neonatal outcomes in the Propylthiouracil group was significantly lower,and time of occurrence of liver function damage in the Propylthiouracil group was significantly later(P<0.05).Conclusion:Both Propylthiouracil and Methimazole can effectively treat pregnancy complicated with hyperthyroidism,but both drugs have adverse reactions.The drug should be selected based on the patients’different conditions,and the vital signs should be closely monitored during treatment,and the abnormal situations should be responded as soon as possible.
作者
施榴红
SHI Liuhong(Nantong Tongzhou District Third People’s Hospital,Nantong 226000,China)
出处
《中外医学研究》
2021年第28期53-56,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
