摘要
目的:观察依达拉奉联合高压氧治疗急性脑出血的效果及对氧化应激、炎性因子水平的影响。方法:选择笔者所在医院于2018年1月-2021年1月收治的急性脑出血患者120例。根据患者接受治疗的方法不同,将120例患者分为研究组和对照组,每组60例。其中对照组给予常规治疗+依达拉奉治疗,研究组在对照组基础上联合高压氧治疗。对比两组患者治疗后的临床效果,治疗前后的氧化应激、炎性因子水平及神经功能(NHISS)和日常生活能力(ADL)。结果:研究组患者的总有效率为93.33%,明显高于对照组的76.67%(P<0.05)。两组患者治疗前的氧化应激、炎性因子水平对比,差异均无统计学意义(P>0.05),治疗后,两组患者的NO、MDA、SOD、IL-1β、TNF-α、CRP均较治疗前改善,且研究组上述指标均明显优于对照组,差异均有统计学意义(P<0.05)。两组患者治疗前的NHISS、ADL评分对比,差异无统计学意义(P>0.05),治疗后,两组患者的NHISS、ADL评分均较治疗前改善,且研究组NHISS评分明显低于对照组,ADL评分明显高于对照组,差异均有统计学意义(P<0.05)。结论:依达拉奉联合高压氧治疗急性脑出血的效果较好,且可有效减轻患者的氧化应激,抑制炎症因子水平,改善患者的神经功能,提高其日常生活能力,具有较高的临床应用价值。
Objective:To observe the effect of Edaravone combined with hyperbaric oxygen in the treatment of acute cerebral hemorrhage and its influence on the levels of oxidative stress and inflammatory factors.Method:A total of 120 patients with acute cerebral hemorrhage admitted to the author’s hospital from January 2018 to January 2021 were selected.According to the different treatment methods of patients,120 patients were divided into the study group and the control group,60 patients in each group.The control group was given conventional treatment+Edaravone treatment,and the study group was combined with hyperbaric oxygen treatment on the basis of the control group.The clinical effects of the two groups of patients after treatment,oxidative stress,inflammatory factor levels,nerve function(NHISS)and ability of daily living(ADL)before and after treatment were compared.Result:The total effective rate of patients in the study group was 93.33%,which was significantly higher than the 76.67%in the control group(P<0.05).There was no significant difference in the levels of oxidative stress and inflammatory factors between the two groups of patients before treatment(P>0.05),but after treatment,the levels of NO,MDA,SOD,IL-1β,TNF-α,and CRP were all improved compared to before treatment,the above indicators of the study group were significantly better than those of the control group,and there were statistically significant differences(P<0.05).The NHISS and ADL scores of the two groups of patients before treatment were not significantly different(P>0.05),but after treatment,the NHISS and ADL scores of the two groups of patients were improved compared to before treatment,and the NHISS score of the study group was significantly lower than that of the control group,ADL score was significantly higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Edaravone combined with hyperbaric oxygen has a good effect in the treatment of acute cerebral hemorrhage,and it can effectively reduce the patients’oxidative stress,inhibit the level of inflammatory factors,improve the neurological function,and improve the ability of daily living.It has a high clinical value.
作者
郭吉卫
GUO Jiwei(Changping District Hospital in Beijing,Beijing 102200,China)
出处
《中外医学研究》
2021年第28期152-155,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
依达拉奉
高压氧
急性脑出血
氧化应激
炎性因子
Edaravone
Hyperbaric oxygen
Acute cerebral hemorrhage
Oxidative stress
Inflammatory factors
