摘要
目的探讨不同年龄段成年女性腰椎骨密度(bone mineral density,BMD)与腰3椎体(L3)层面体质成分的相关性。方法将496名成年女性按年龄分为青年组(≤44岁)、中年组(45~59岁)、老年组(≥60岁),计算体质量指数(body mass index,BMI),采用定量CT(quantitative computed tomography,QCT)测量L1~3椎体BMD及L3椎体中心层面周围各体质成分含量,包括BMI、椎体周围脂肪含量(FM)、瘦组织含量(LM)、脂肪与瘦组织比值(F/L)、骨量与瘦组织比值(B/L)、腹部总脂肪(TAT)、内脏脂肪(VAT)、皮下脂肪(SAT)。依据BMD分为骨量正常组(≥120 mg/cm3)、骨量减少组(80~120 mg/cm3)和骨质疏松(≤80 mg/cm3,OP)组。通过单因素方差分析不同年龄组BMI、BMD及各体质成分的组间差异。利用线性相关分析BMD与各体质成分的相关性。结果研究对象平均年龄(50.9±12.5)岁(25~82岁)。BMI、BMD、LM、SAT值在老年组低于中、青年组,组间差异有统计学意义(P<0.01),FM在老年组高于中、青年组(P<0.01)。VAT随年龄增加逐渐减低,组间差异无统计学意义(P=0.955)。BMD与年龄、FM呈负相关,与BMI、LM、SAT呈正相关,与VAT呈较弱正相关。在不同BMD组中,BMI、LM、SAT在骨质疏松组中最低,组间差异有统计学意义(P<0.01),FM在骨质疏松组中最高(P<0.01),而VAT在不同BMD组间差异无统计学意义(P=0.701)。结论女性腰椎周围肌肉含量、脂肪浸润程度、腹部皮下及内脏脂肪与腰椎BMD存在相关性,其中BMI、LM、SAT与BMD呈正相关,而FM与BMD呈负相关。
Objective To investigate the relationship between lumbar vertebral bone mineral density(BMD)and the body composition at the third lumbar vertebra(L3)level in adult women with different age.Methods A total of 496 adult females aged from 25-82 years were divided into youth group(≤44 years old),middle-aged group(45-59 years old),and elderly group(≥60 years old).Quantitative computed tomography(QCT)was used to measure BMD of L1-3 and the content of paravertebral body compositions at L3 level.Statistical analysis was performed using one-way ANOVA and independent-samples t test in different age and BMD groups.Results The average age of the subjects was 50.9±12.5 years(25-82 years).The values of BMI,BMD,LM,and SAT in the elderly group were lower than those in the young and middle-aged groups(P<0.01).FM was higher in the elderly group than in the middle and young group(P<0.01).VAT gradually decreased with age,but there was no statistically significant difference among the groups(P=0.955).BMD was negatively correlated with age and FM,and positively correlated with BMI,LM,SAT,and weakly positively correlated with VAT.Among the different BMD groups,BMI,LM,and SAT were the lowest in the osteoporosis group(P<0.01),FM was the highest in the osteoporosis group(P<0.01),and VAT was not statistically different between the different BMD groups(P=0.701).Conclusion In women,BMD and body composition display different characteristics with age.BMI,LM,and SAT are positively correlated with BMD.However,FM is negatively correlated with BMD.
作者
张雪丽
陈明月
唐睿
万丽娣
彭鲲
董丽君
汤光宇
张琳
ZHANG Xueli;CHEN Mingyue;TANG Rui;WAN Lidi;PENG Kun;DONG Lijun;TANG Guangyu;ZHANG Lin(Department of Radiology,the Tenth Shanghai People’s Hospital,School of Medicine,Tongji University,Shanghai 200072,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2021年第11期1566-1571,共6页
Chinese Journal of Osteoporosis
基金
国家自然科学基金面上项目(81871325)
上海市科委“科技创新行动计划”(20Y11911800)。
关键词
体质成分
骨质疏松
骨密度
成年女性
定量CT
body composition
bone mineral density
osteoporosis
female
quantitative computed tomography
