摘要
目的探讨糖肾康治疗2型糖尿病肾病的临床疗效及对脂质代谢紊乱状态的调节作用。方法选择2018年8月—2020年8月医院收治的2型糖尿病肾病患者106例,依据随机对照法将患者分为观察组和对照组,每组63例。对照组给予西药常规治疗,在饮食调节、运动、生活方式干预等治疗基础上,皮下注射胰岛素以降糖,口服贝那普利以降压,口服他汀类药物调脂。观察组在对照组治疗的基础上,口服糖肾康治疗。两组均治疗8周。比较两组治疗疗效,治疗前后中医证候积分,比较两组治疗前后血糖指标(FPG、2hPG和HbA1c)、肾功能相关指标(SCr、BUN、UAER和Uβ2-MG)、脂代谢指标(TG、TC、LDL-C和HDL-C)。结果观察组治疗总有效率为87.30%(55/63)高于对照组治疗总有效率的73.02%(46/63)(P<0.05);观察组治疗后神疲乏力、腰膝酸软、发脱齿摇、肢体麻木、耳聋耳鸣和面色晦暗等中医证候积分低于对照组(P<0.05);观察组治疗后FPG、2hPG和HbA1c水平低于对照组(P<0.05);观察组治疗后SCr、BUN、UAER和Uβ2-MG低于对照组(P<0.05);观察组治疗后脂代谢指标TG、TC、LDL-C高于对照组,HDL-C水平高于对照组(P<0.05)。结论糖肾康结合西药常规治疗2型糖尿病肾病疗效确切,可有效的降低肾虚血瘀证患者的中医证候积分,改善患者的糖代谢、脂代谢指标,保护肾脏功能,延缓病情进展,提高治疗效果,值得进一步研究探讨。
e Objective To investigate the clinical efficacy of Tangshenkang(糖肾康)in the treatment of type 2 diabetic ne-phropathy and its regulation effect on lipid metabolism disorder.s Methods A total of 106 patients with type 2 diabetic nephropathy admitted to our hospital from August 2018 to August 2020 were selected.According to the randomized control method,the pa-tients were divided into observation group and control group,with 63 patients in each group.The control group was given routine western medicine treatment.On the basis of diet regulation,exercise,lifestyle intervention and other basic treatments,insulin was injected subcutaneously to lower glucose.Benazepil was taken orally to lower blood pressure,and statins were taken orally to lower lipid.On the basis of treatment in the control group,the observation group used Tangshenkang orally.Both groups were treated for 8 weeks.The therapeutic effect of the two groups was compared,and the scores of traditional Chinese medicine syn-drome before and after treatment were compared.Blood glucose indexes(FPG,2 hPG and HbA1c),renal function related inde-xes(SCr,BUN,UAER and Uβ2-MG),lipid metabolism indexes(TG,TC,LDL-C and HDL-C)were compared between the two groups before and after treatment.s Results The total effective rate[87.30%(55/63)]in the observation group was higher than that[73.02%(46/63)]in the control group(P<0.05).After treatment,the scores of TCM syndromes in the observation group were lower than those in the control group(P<0.05).The levels of FPG,2 hPG and HbA1c in the observation group were lower than those in the control group(P<0.05).After treatment,SCr,BUN,UAER and Uβ2-MG in the observation group were lower than those in the control group(P<0.05).After treatment,lipid metabolism indexes TG,TC and LDL-C in the ob-servation group were higher than those in the control group,and HDL-C level was higher than that in the control group(P<0.05).n Conclusion The combination of Tangshenkang and western medicine in the conventional treatment of type 2 diabetic nephropathy has a definite effect,and can effectively reduce the TCM syndrome score of patients with kidney deficiency and blood stasis syndrome,improve the indicators of glucose metabolism and lipid metabolism in patients,protect the renal function,delay the progression of the disease,and improve the therapeutic effect.It is worthy of further research and discussion.
作者
裴文丽
史晓伟
连琯
张定华
张东鹏
丁玉芬
聂晓燕
陈秀萍
PEI Wenli;SHI Xiaowei;LIAN Guan;ZHANG Dinghua;ZHANG Dongpeng;DING Yufen;NIE Xiaoyan;CHEN Xiuping(Department of Endocrinology,Gansu Provincial Hospital of Chinese Medicine,Lanzhou 730050,Gansu,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第10期142-145,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金地区项目基金(81460699)。
关键词
糖肾康
2型糖尿病肾病
血糖
肾功能
脂质代
影响
Tangshenkang(糖肾康)
type 2 diabetic nephropathy
blood sugar
renal function
lipid generation
impact
