摘要
目的:探讨特布他林联合布地奈德雾化吸入治疗婴幼儿毛细支气管炎的临床效果及对肺功能的影响。方法:选取82例毛细支气管炎患儿,按照随机数字表法将其分为两组,每组各41例。对照组予以布地奈德治疗,观察组在对照组基础上加用特布他林治疗,两组均持续治疗7 d。比较两组临床疗效、肺功能指标、症状及体征改善时间,并观察不良反应。结果:观察组总有效率高于对照组,有统计学差异(P<0.05);治疗后,观察组FRC、Reff低于对照组,VT、tPTEF/tE高于对照组,喘憋、咳嗽及肺部啰音改善时间短于对照组,以上均具有统计学差异(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论:特布他林与布地奈德联用可提高毛细支气管炎治疗效果,促进患儿肺功能恢复,安全可靠。
Objective:To investigate the clinical efficacy of terbutaline combined with budesonide nebulized inhalation in the treatment of infant bronchiolitis and its influence on lung function in infants or children.Methods:A total of 82 children with bronchiolitis were randomized into two groups,each with 41 cases.The control group were treated with budesonide,while the observation group were treated with terbutaline on the basis of the treatment for the control group.The treatment lasted for 7 days in both groups.Then,the clinical efficacy,pulmonary function indicators,the improvement time of symptoms and signs,and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,which was of statistical difference(P<0.05);FRC and Reff of the observation group were lower than that of the control group after treatment,but VT and tPTEF/tE were higher than that of the control group,and the improvement time of wheezing,coughing and lung rales was shorter than that of the control group,and these were statistical different between both groups(P<0.05);and there was no statistical difference of adverse reactions between both group(P>0.05).Conclusion:The combination of terbutaline with budesonide can improve the therapeutic effect of bronchiolitis,promote the recovery of lung function in children,which is safe and reliable.
作者
谈江波
李莲
黄伟
任庆龙
石欣
袁卫荣
TAN Jiangbo;LI Lian;HUANG Wei;REN Qinglong;SHI Xin;YUAN Weirong(Dept.of Pediatrics,Yichun Hospital of Traditional Chinese Medicine,Yichun 336000,China)
出处
《华夏医学》
CAS
2021年第5期14-17,共4页
Acta Medicinae Sinica
