摘要
目的:研究毓麟汤结合督任灸对卵巢早衰临影响,探究治疗效果及安全性。方法:符合纳入标准的105例卵巢早衰患者以随机数字表随机分成观察组(53例)和对照组(52例),对照组采取补佳乐+黄体酮胶囊治疗,观察组在对照组治疗基础上结合毓麟汤及督任灸治疗,比较各组患者临床疗效以及治疗前后生殖内分泌激素水平、中医证候积分、子宫卵巢超声影像学指标变化、治疗安全性情况等。结果:对照组治疗总有效率(84.62%,44/52)低于观察组(96.23%,51/53)(P<0.05);两组均未见明显不良反应(P>0.05);治疗前,两组患者促卵泡激素(FSH)、雌二醇(E2)等生殖内分泌激素水平、中医证候积分比较无统计学意义,治疗后各组患者FSH及E2水平、中医证候积分均改善,且观察组患者治疗后FSH及E2水平、中医证候积分优于对照组(P<0.05);治疗前后两组患者子宫体积及卵巢体积、双侧卵巢基质内血流阻力指数(RI)均无明显变化(P>0.05);治疗前两组患者子宫内膜厚度及双侧卵巢基质内血流的收缩期峰值流速(PSV)指标比较无统计学意义;治疗后两组患者子宫内膜厚度增厚,PSV指标升高,观察组治疗后子宫内膜厚度及PSV指标改善情况均优于对照组(P<0.05)。结论:毓麟汤结合督任灸治疗卵巢早衰效果良好,无不良反应,安全可靠,值得临床应用。
Objective:To study the effect of Yulin Decoction combined with Du and Ren moxibustion on premature ovarian failure(POF)and to explore therapeutic effect and safety of the therapy.Methods:105 cases of POF were randomly divided into the observation group(n=53)and the control group(n=52).The control group was treated with Bujiele plus progesterone capsule;on which basis,the observation group was also treated with Yulin Decoction and Du and Ren moxibustion.Endocrine hormone levels,TCM syndrome integral and ultrasound imaging indicators of uterus and ovary were compared between before and after the treatment in the two groups.Clinical efficacy and treatment safety were also compared between the two groups.Results:The total effective rate was 96.23%in the observation group,which was significantly higher than 84.62%in the control group(P<0.05).No obvious adverse reactions were shown in both groups(P>0.05).There were no statistical differences in the levels of FSH,E_(2) and TCM syndrome integral between the two groups before the treatment(P>0.05);which were significantly improved after the treatment in the two groups,and the improvements were more significant in the observation group(P<0.05).There were no significant changes in uterine volume,ovarian volume and bilateral intra-stromal blood flow resistance index(RI)before and after the treatment in the two groups(P>0.05).There were no statistical differences in endometrial thickness and systolic peak flow velocity(PSV)in bilateral ovarian intra-stromal blood flow between the two groups before the treatment(P>0.05);which were significantly increased in the two groups after the treatment,and the increases in the observation group were more significant(P<0.05).Conclusion:Yulin Decoction combined with Du and Ren moxibustion has a good curative effect for POF,with no obvious adverse reactions.The therapy is safe and reliable,which is worthy of clinical application.
作者
石艳阁
温海莹
SHI Yange;WEN Haiying(Luoyang Maternal and Child Health Hospital,Luoyang 471900,China;Luoyang First People's Hospital,Luoyang 471900,China)
出处
《中医药信息》
2021年第11期71-74,共4页
Information on Traditional Chinese Medicine
关键词
卵巢早衰
毓麟汤
督任灸
生殖内分泌激素
中医证候积分
Premature ovarian failure
Yulin Decoction
Du and Ren moxibustion
Reproductive endocrine hormone
TCM syndrome integral
