摘要
羌活为伞形科植物羌活Notopterygium incisum或宽叶羌活Notopterygium franchetii干燥后的根茎和根,从其中分离得到的主要化学成分包括挥发油及萜类、香豆素类、糖及糖苷类、酚酸类、聚烯炔、生物碱类等。药理研究表明,羌活具有抗炎抗菌、抗氧化、抗病毒、抗癌细胞增殖、解热镇痛等活性,且对心脑血管系统、消化系统、呼吸系统和中枢神经系统有显著影响。主要介绍中药羌活的化学成分及药理活性研究进展,并对其研究方向进行展望,为进一步研究其药效物质基础、作用机制及合理开发利用提供理论依据。
Notopterygii Rhizoma et Radix consists of two species of Notopterygium(Umbelliferae), N. incisum Ting ex H. T. Chang and N. forbesii De Boiss. The main chemical constituents isolated from this herb include volatile oils and terpenes, coumarins, sugars, glycosides, phenolic acids, polyalkynes and alkaloids. Pharmacological studies have shown that Notopterygii Rhizoma et Radix has anti-inflammatory, antibacterial, antioxidant, antiarrhythmic, and anti-cancer, antipyretic and analgesic activities, and has positive effects on the cardiovascular, digestive, respiratory and central nervous systems. This review mainly summarized the research progress of the main chemical constituents and pharmacological activities of Notopterygii Rhizoma et Radix, and prospected its research direction, and provided theoretical basis for further research on its substance basis, mechanisms of pharmacological actions, reasonable development and utilization.
作者
马丽梅
杨军丽
MA Li-mei;YANG Jun-li(CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences(CAS),Lanzhou 730000,China;University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第19期6111-6120,共10页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81673325)
甘肃省重点研发计划国际科技合作专项(18YF1WA)
中国科学院百人计划人才项目。
关键词
羌活
宽叶羌活
挥发油
萜类
香豆素类
糖及糖苷类
酚酸类
聚烯炔
生物碱类
抗炎抗菌
抗氧化
抗病毒
抑制细胞增殖
Notopterygii Rhizoma et Radix
N.franchetii H.de Bioss
volatile oils
terpenes
coumarins
sugars
glycosides
phenolic acids
polyalkynes
alkaloids
anti-inflammatory
antioxidant
antiarrhythmic
anti-cancer
