摘要
目的研究铜绿假单胞菌注射液对乳腺癌改良根治术后病人免疫功能及引流的影响。方法前瞻性收集2020年4月至2021年6月于中国医科大学附属盛京医院第一乳腺外科收治的64例拟行乳腺癌改良根治术的病人,根据病人知情同意分为两组:未应用组(25例,术中未应用铜绿假单胞菌注射液)和应用组(39例,术中应用铜绿假单胞菌注射液),比较分析两组病人术后7 d内引流量情况;根据血液检查结果资料分为对照组(20例)和试验组(27例),比较分析两组病人术后第4天免疫学指标。结果试验组和对照组病人比较,免疫球蛋白IgA、IgG、IgM、T抑制毒细胞、T辅助细胞差异无统计学差异(P>0.05);术后总B细胞差异有统计学意义(P<0.05),试验组术后总B细胞升高更明显;应用组术后第2~7天内每日胸壁及腋窝引流量、第2~7天胸壁及腋下引流量总量与未应用组相比均减少,差异有统计学意义(P<0.05);应用组胸壁带管时间、腋下带管时间与未应用组相比明显缩短,差异有统计学意义(P<0.05);超重病人较正常体重病人胸壁与腋下带管时间延长(P<0.05);不同手术清扫范围对于引流管留置时间无影响(P>0.05)。结论铜绿假单胞菌注射液可减少病人术区引流量,缩短引流管留置时间,同时可以为提高病人的免疫功能奠定一定的基础。
Objective To study the effect of pseudomonas aeruginosa injection on immune function and drainage of patients after modified radical mastectomy.Methods From April 2020 to June 2021,64 patients undergoing modified radical mastectomy in the First Breast Surgery Department of Shengjing Hospital affiliated to China Medical University were prospectively collected,who were divided into two groups according to the informed consent of the patients:25 in the non-applied group(not using pseudomonas aeruginosa injection during operation)and 39 in the applied group(using pseudomonas aeruginosa injection during operation).The drainage volume within 7 days after the operation were analiyzed;These patients were also divided into the control group(20 cases)and experimental group(27 cases),according to blood test results.The immunological indicators on the 4th day after surgery in two groups were compared and analyzed.Results There was no significant difference in the expression of immunoglobulin(IgA,IgG and IgM),numbers of total T cells,T suppressor cells and T helper cells between the control group and experimental group(P>0.05)There was a significant difference in total B cells between the two groups(P<0.05),and the total numbers of B cells in the experimental group increased after operation.Compared with the non-applied group,daily drainage volume of chest wall and armpit in the 2-7 days after operation and the total drainage volume of chest wall and armpit in the 2-7 days after operation in the applied group decreased significantly(P<0.05),time of chest wall tube and armpit tube in the applied group was significantly shorter(P<0.05).Compared with normal weight patients,overweight patients had longer chest wall and armpit tube time(P<0.05).There was no significant difference in the time when the drainage tube was taken with different surgical scope(P>0.05).Conclusion Pseudomonas aeruginosa injection can reduce the drainage volume in patients'operation area,shorten the time of drainage tube,and improve the cellular immune function of patients.
作者
刘盼
赵毅
LIU Pan;ZHAO Yi(Shengjing Hospital Affiliated to China Medical University,Shenyang 110014,China)
出处
《中国实用外科杂志》
CAS
CSCD
北大核心
2021年第11期1277-1281,共5页
Chinese Journal of Practical Surgery
基金
辽宁省自然科学基金(No.2019-ZD-0780)。
关键词
铜绿假单胞菌注射液
乳腺癌改良根治术
引流量
免疫功能
pseudomonas aeruginosa injection
modified radical mastectomy
drainage
immunologic function
